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FRONTLINE Plus for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) 6 Doses (Purple Box)

4.5 4.5 out of 5 stars 13,621 ratings
Amazon's Choice highlights highly rated, well-priced products available to ship immediately.
Amazon's Choice in Dog Flea Drops by Frontline

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About this item

  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease.
  • Break the flea life cycle with FRONTLINE Plus. Specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control.
  • Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days.
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products.
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations.
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus.

Customer ratings by feature

Easy to use
4.0 4.0
Scent
4.0 4.0
Easy to remove
3.6 3.6
Value for money
3.1 3.1

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FRONTLINE Plus for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) 6 Doses (Purple Box)
FRONTLINE Plus for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) 6 Doses (Purple Box)
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Price$78.98$94.99-13% $54.99
List:$62.99
$79.98-12% $79.98
List:$91.18
-26% $59.98
List:$81.58
Delivery
Get it as soon as Tuesday, Mar 26
Get it as soon as Tuesday, Mar 26
Get it as soon as Tuesday, Mar 26
Get it as soon as Tuesday, Mar 26
Get it as soon as Tuesday, Mar 26
Get it as soon as Tuesday, Mar 26
Customer Ratings
Easy to use
4.0
4.4
4.4
4.2
4.2
5.0
Value for money
3.1
3.8
3.8
3.4
3.5
3.4
Comfort
3.0
4.6
4.6
3.6
3.5
4.1
Scent
4.0
4.4
4.4
3.7
3.9
Flavor
2.6
2.6
2.8
Sold By
Amazon.com
Amazon.com
Amazon.com
Amazon.com
Amazon.com
Amazon.com
target audience
Dog, Dog, Dog, Dog, Dog
Adult
Adult
Dog
Dog
age range
Senior
All Life Stages
All Life Stages
7 weeks and older
7 weeks and older
7 weeks and older
scent
Unscented
No Scent
No Scent
Unscented
Unscented
form
Topical
Stick
Stick
Topical
Topical
Collar
volume
1 milliliters
16.08 milliliters
8.04 milliliters
1 quarts
24 milliliters
active ingredients
fipronil and (S)-methoprene
Fipronil, (S)-methoprene, Pyriproxyfen
Fipronil, (S)-methoprene, Pyriproxyfen
Imidacloprid, Permethrin, Pyriproxyfen
Imidacloprid, Permethrin, Pyriproxyfen
Imidacloprid, Flumethrin

From the brand


From the manufacturer

Smiling man playing fetch outside with healthy dog. Frontline Plus awarded Newsweek most trusted
Frontline Plus has been trusted by pet owners for over 20 years and kills fleas and chewing lice
Answers to frequently asked questions about Frontline flea and tick prevention and treatment plans

How to Apply FRONTLINE Plus for Dogs

Step one woman reading instructions on pack before applying flea and tick non prescription treatment

Step two woman holding applicator upright and away from her face before opening by snapping off tip

Step three prep dog for flea treatment application by using fingers to part fur so skin is visible

Step four place the open applicator to dogs skin and squeeze out all contents on dog

Read full instructions on packaging before use. Shown here: Size Large 45-88 lbs.

Use scissors to separate one blister. Hold applicator upright with foil side toward you and snap applicator tip off.

Part dog’s hair between shoulder blades until skin is visible.

Place applicator tip directly against exposed skin and apply entire contents directly to the skin. Do not apply on top of hair.

Pack of Frontline Plus for small dog breeds tratamiento de pulgas y garrapatas para perros pequenos Pack of Frontline Plus for medium dog breeds medicina para matar pulgas y garrapatas Pack of Frontline Plus for large dog breeds prevención de pulgas y garrapatas para perros grandes Pack of Frontline Plus for xl dog breeds control de pulgas y garrapatas para perros extra grandes Frontline Plus Cat
FRONTLINE Plus for Small Dogs FRONTLINE Plus for Medium Dogs FRONTLINE Plus for Large Dogs FRONTLINE Plus for X-Large Dogs FRONTLINE Plus for Cats
Customer Reviews
4.4 out of 5 stars
43,518
4.4 out of 5 stars
20,938
4.5 out of 5 stars
13,621
4.6 out of 5 stars
3,618
4.4 out of 5 stars
43,293
Recommended pet size 5 to 22 pounds 23 to 44 pounds 45 to 88 pounds 89 to 132 pounds Cats and kittens over 1.5 pounds
Kills adult fleas, flea eggs, and flea larvae
Kills ticks and chewing lice
Minimum age of pet for use Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Cats and kittens 8 weeks and older
Available sizes 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose
Do not use on cats Do not use on cats Do not use on cats Do not use on cats For use on cats only

Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 5.75 x 1 x 4.5 inches; 0.2 ounces
  • Item model number ‏ : ‎ 72219
  • Department ‏ : ‎ Pet Supplies
  • Date First Available ‏ : ‎ October 2, 2001
  • Manufacturer ‏ : ‎ Boehringer Ingelheim Animal Health
  • ASIN ‏ : ‎ B0002J1FOO
  • Country of Origin ‏ : ‎ France
  • Customer Reviews:
    4.5 4.5 out of 5 stars 13,621 ratings

Product guides and documents

Product Description

Product Description

Keep your dog protected with the #1 name in flea & tick protection*, FRONTLINE®. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years**— FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: *Data on file at Boehringer Ingelheim. **Data showing 20 years of trust in killing fleas and ticks is on file at Boehringer Ingelheim.

Brand Story

By Frontline Plus

Looking for specific info?

Important information

Safety Information

KEEP OUT OF REACH OF CHILDREN. WARNING: PRECAUTIONARY STATEMENTS - HAZARDS TO HUMANS: WARNING. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid Contact with skin. Harmful if swallowed. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash clothing that may have come in contact with the product before reuse. HAZARDS TO DOMESTIC ANIMALS: For external use on dogs ONLY. Do not use on animals other than dogs. Do not use on dogs under 9 weeks of age or weighing less than 5 lbs. Individual sensitivities may occur after using ANY pesticide product. Dogs may experience some temporary irritation at the site of product application. If signs of sensitivity occur, bathe your dog with mild soap or shampoo and rinse with large amounts of water. If signs of sensitivity occur and persist, contact a veterinarian immediately. If your dog has an unusual reaction to the initial application, consult a veterinarian before repeating application. Certain medications can interact with pesticides. Consult a veterinarian before using on medicated, debilitated, aged, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products. Consult a veterinarian for guidance on use against Sarcoptes mites. This product is not a substitute for a prescribed heartworm preventative.nCall 1-888-637-4251, for assistance. PHYSICAL OR CHEMICAL HAZARDS: Do not allow this product to come in contact with an oxidizing agent, as a hazardous chemical reaction may occur Harmful if swallowed. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid contact with skin. Wear (specify appropriate protective eyewear such as goggles, face shield, or safety glasses). Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash contaminated clothing before reuse.

Ingredients

Fipronil (9.8%)|(S)-Methoprene (8.8%)

Directions

Directions for Use Step 1. To REMOVE Applicator: 1. Use scissors to separate one blister; 2. Use scissors to cut along dotted line; 3. Peel down foil to remove the applicator. Step 2. OPEN Applicator. Hold upright with foil side toward you and snap applicator tip. Step 3. APPLY FRONTLINE Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the dog’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Do not allow your dog to ingest the product. Do not apply to dogs weighing less than 45 lbs. or younger than 8 weeks of age. Do not use more than one application per dog per month. Frequency Use monthly to control fleas and ticks. Do not reapply FRONTLINE Plus for 30 days.

Legal Disclaimer

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product.

Customer reviews

4.5 out of 5 stars
4.5 out of 5
13,621 global ratings

Customers say

Customers like the side effects and value of the pet supplies. For example, they mention it helps keep pets healthy and is good value for money. Some are happy with ease of use, and quality. That said, opinions are mixed on fleas, scratching, performance, and ticks.

AI-generated from the text of customer reviews

490 customers mention356 positive134 negative

Customers like the value of the pet supplies. They say it's worth the extra money, works well, and is cheap.

"Compared to a lot of dog flea and tick medicine, this is a reasonable price. Always ships on time as well...." Read more

"...exceed 750PPM companies continue to ignore the guidline because it's cheap and effective, and sadly it's our dogs that pay the price...." Read more

"...It's easy to apply, but as it only lasts a month, it can get expensive. But then again, it's worth it to avoid another fleafestation." Read more

"Good value" Read more

201 customers mention198 positive3 negative

Customers are satisfied with the quality of the pet supplies. They mention that it is a great product, easy to apply, and genuine. Some say that the product stands up to swimming and that the fleas begin to die within the first 30 minutes.

"...The day after that, we had 2 different dogs. They have been so peaceful and restful since we applied this. I have not seen them scratch one time...." Read more

"...Their coats are shiny, they're not scratching every two seconds, and they've even started to learn new tricks...." Read more

"...My shipment did come directly from Amazon so I am happy to know it is genuine and safe to use on my 80# dog...." Read more

"The quality is there and it seems safe to use on him" Read more

121 customers mention112 positive9 negative

Customers find the pet supplies easy to use. They mention it's easy to apply once a month, and has never experienced any side-effects. The application process is as smooth as butter, and it comes right to their door, making it more convenient.

"...The application process was as smooth as butter (or should I say, peanut butter – my doggos' favorite treat)...." Read more

"...Also, a problem here. So easy to apply and I don't detect a scent at all." Read more

"This products works well on my three huskies. Easy to apply. The dog don’t mind me applying it to there back." Read more

"...It's easy to apply, but as it only lasts a month, it can get expensive. But then again, it's worth it to avoid another fleafestation." Read more

70 customers mention56 positive14 negative

Customers like the side effects of the pet supplies. They say it has the least effect on their animals, helps keep them healthy, and is great for their immune system. Some customers also mention that their dogs appear happier and are free of fleas, ticks, and lice.

"...It dries pretty quickly. This is perfect for my dogs that like to roll around in the grass and could bring anything in the house...." Read more

"...works better for ticks than Advantix/Advantage and is a better choice for cat owners (we used to have a cat, too)...." Read more

"Very easy to administer. Keeps all the crazy bugs away." Read more

"...is essentially a poison to ticks and fleas, it also has a short term effect on the dog (usually mild diarrhea)...." Read more

763 customers mention410 positive353 negative

Customers are mixed about the performance of the pet supplies. Some mention that it works just as good as the vet flea medicine, is effective, and cheap. However, others say that it doesn't seem effective at all anymore, works for about a week then stops working, and is useless.

"...companies continue to ignore the guidline because it's cheap and effective, and sadly it's our dogs that pay the price...." Read more

"...This makes me suspect that it is not quite as effective as it would be on a dog at 45 lbs...." Read more

"This products works well on my three huskies. Easy to apply. The dog don’t mind me applying it to there back." Read more

"...However, two of my dogs (littermates) had a weird reaction to it...." Read more

431 customers mention285 positive146 negative

Customers are mixed about the fleas. Some mention that the product does keep them from getting flea, while others say that it didn't keep flea off.

"...Always ships on time as well. My dog has had no issues with fleas or ticks since using this brand." Read more

"Must be watered down because it didnt keep fleas off but for about a week and 1/2. I wont buy Frontline product anymore." Read more

"This is hands-down the best flea and tick preventative made...." Read more

"...And while I wonder how it affects a dog's health, it does keep them from getting fleas...." Read more

94 customers mention64 positive30 negative

Customers are mixed about the ticks. Some mention that it eliminates a lot of ticks, while others say that it doesn't seem to repel them.

"...This pretty much removed all the ticks and most of the fleas. With regular use we hardly ever see a flea...." Read more

"This worked great on my dogs! I did not find any ticks on them a couple of days after applying. Feel sure it is the real deal!..." Read more

"...This year towards the end of summer we started noticing ticks on the dogs...." Read more

"...No fleas, no ticks, no problems." Read more

77 customers mention31 positive46 negative

Customers are mixed about the scratching with some customers saying it doesn't cause irritation or rashes, and it stops scratching after a day of treating their pet. However, other customers say it makes their pets itchy and makes them scratch and bite like crazy.

"...It's pretty nasty stuff, you're supposed to avoid getting in on your skin and wash your hands immediately afterwards...." Read more

"...Their coats are shiny, they're not scratching every two seconds, and they've even started to learn new tricks...." Read more

"...developed a horrible smell as it reacted to their skin, and they began itching and scratching furiously at the application site...." Read more

"...These drops work well, without making her itchy." Read more

Authentic and Very Effective
5 Stars
Authentic and Very Effective
This is the real deal. I was leery after reading other posts from people saying their's was not legitimate. I think they older ones, from different sellers might be fake, but I think some of them are looking for a fake more than they are looking for evidence that it is not. This is the first time I bought these off Amazon and this is what I found (photos to show)I made sureit said "Ships from and sold by Amazon.com" ✓Frontline inserts were in box ✓the applicators had spaces between them ✓the lot # on the applicator matched the lot number on the box ✓the applicators each said Merial ✓each applicator had instructions on how to open✓The box I got did not look like the box on Amazon site, which worried me as it was the first thing I noticed. But I looked on Frontline's website and the 45 - 88 lb box they show looks like mine. The one on Amazon is an older model box, apparently.Here is the real proof and the reason for my 5 stars.I have two labs. They are outdoor dogs(except for thunderstorms, snow, cold, etc) and they have never really had a problem with fleas before. When I take them to the groomers and ask if they had fleas, they usually say "one or two" but this year they were suffering. We noticed it and I immediately went to my trusty Amazon to see if it was sold, and I found all the concerns. I trust Amazon, so I ordered. As I am a prime member I knew I would get 2 days shipping, The next day I felt like a horrible dog owner. They were both whining and I could see fleas. They were miserable. The next day the package came in and I immediately did my check offs to prove it was legit. When it passed, we applied to our dogs. That night it was thundering so the babies came in. They sleep on their own indoor blankets. They were still itching but the next morning, we saw dead fleas all over the blanket. The day after that, we had 2 different dogs. They have been so peaceful and restful since we applied this. I have not seen them scratch one time. And we have not been able to find a flea or tick on them. I bought the 6 pack which will last my 2 dogs 3 months and I will apply again. If you are debating on whether to purchase or not, go ahead. I have the photos to prove it is legit, and the happy dogs as more proof If I could give it 10 stars I would. If someone had a way to convince me this was not authentic, I would still buy it because my dogs are proof enough to me that it works. But I believe it to be 100% legitimate.
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Top reviews from the United States

Reviewed in the United States on June 9, 2015
Customer image
5.0 out of 5 stars Authentic and Very Effective
Reviewed in the United States on June 9, 2015
This is the real deal. I was leery after reading other posts from people saying their's was not legitimate. I think they older ones, from different sellers might be fake, but I think some of them are looking for a fake more than they are looking for evidence that it is not. This is the first time I bought these off Amazon and this is what I found (photos to show)
I made sure
it said "Ships from and sold by Amazon.com" ✓
Frontline inserts were in box ✓
the applicators had spaces between them ✓
the lot # on the applicator matched the lot number on the box ✓
the applicators each said Merial ✓
each applicator had instructions on how to open✓
The box I got did not look like the box on Amazon site, which worried me as it was the first thing I noticed. But I looked on Frontline's website and the 45 - 88 lb box they show looks like mine. The one on Amazon is an older model box, apparently.
Here is the real proof and the reason for my 5 stars.I have two labs. They are outdoor dogs(except for thunderstorms, snow, cold, etc) and they have never really had a problem with fleas before. When I take them to the groomers and ask if they had fleas, they usually say "one or two" but this year they were suffering. We noticed it and I immediately went to my trusty Amazon to see if it was sold, and I found all the concerns. I trust Amazon, so I ordered. As I am a prime member I knew I would get 2 days shipping, The next day I felt like a horrible dog owner. They were both whining and I could see fleas. They were miserable. The next day the package came in and I immediately did my check offs to prove it was legit. When it passed, we applied to our dogs. That night it was thundering so the babies came in. They sleep on their own indoor blankets. They were still itching but the next morning, we saw dead fleas all over the blanket. The day after that, we had 2 different dogs. They have been so peaceful and restful since we applied this. I have not seen them scratch one time. And we have not been able to find a flea or tick on them. I bought the 6 pack which will last my 2 dogs 3 months and I will apply again. If you are debating on whether to purchase or not, go ahead. I have the photos to prove it is legit, and the happy dogs as more proof If I could give it 10 stars I would. If someone had a way to convince me this was not authentic, I would still buy it because my dogs are proof enough to me that it works. But I believe it to be 100% legitimate.
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