No featured offers available Learn more

No featured offers available

We feature offers with an Add to Cart button when an offer meets our high standards for:

  • Quality Price,
  • Reliable delivery option, and
  • Seller who offers good customer service
“No featured offers available” means no offers currently meet all of these expectations. Select See All Buying Options to shop available offers.

Select delivery location
Added to

Sorry, there was a problem.

There was an error retrieving your Wish Lists. Please try again.

Sorry, there was a problem.

List unavailable.

FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs., 8 Treatments

4.6 4.6 out of 5 stars 1,887 ratings

To see product details, add this item to your cart. You can always remove it later.

About this item

  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease.
  • Break the flea life cycle with FRONTLINE Plus. Specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control.
  • Trusted by pet owners for over 20 years**, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days.
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products.
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations.
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus.

Additional Details

Verified by Transparency
The brand applies a unique Transparency code to each item. We verify this code before shipping. You can verify this code using the Amazon Shopping app to confirm it comes from the brand and view additional product details.
Verified by Transparency
Each item has a unique code that we verify before shipping. Learn more

Customer ratings by feature

Easy to use
4.3 4.3
Scent
3.6 3.6
Water resistance
3.5 3.5
Value for money
3.4 3.4

Compare with similar items

This Item
FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs., 8 Treatments
FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs., 8 Treatments
Recommendations
FRONTLINE Gold Flea & Tick Treatment for Large Dogs Up to 45 to 88 lbs., Pack of 3
dummy
Frontline Gold Flea & Tick Treatment for Large Dogs Up to 45 to 88 lbs., Pack of 6
dummy
FRONTLINE Shield Flea & Tick Treatment for X-Large Dogs 81-120 lbs., Count of 3
dummy
Frontline Gold Flea & Tick Treatment for X-Large Dogs Up to 89 to 132 lbs., Pack of 3
dummy
PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 12 Doses, Waterproof Topical, Fast Acting, X-Large Dogs (89-132 lbs)
Details
Added to Cart
Details
Added to Cart
Details
Added to Cart
Details
Added to Cart
Details
Added to Cart
Price-13% $54.99
List:$62.99
$94.99$46.98-13% $54.99
List:$62.99
$79.96
Delivery
Get it as soon as Monday, Apr 1
Get it as soon as Monday, Apr 1
Get it as soon as Monday, Apr 1
Get it as soon as Wednesday, Apr 3
Get it as soon as Monday, Apr 1
Customer Ratings
Easy to use
4.3
4.4
4.4
4.2
4.7
4.0
Scent
3.6
4.4
4.4
3.3
3.0
3.4
Value for money
3.4
3.8
3.8
3.1
3.8
3.0
Flavor
3.2
2.6
2.6
3.4
2.4
Comfort
4.6
4.6
3.1
Sold By
Amazon.com
Amazon.com
Amazon.com
Amazon.com
Amazon.com
target audience
Dogs
Adult
Adult
Dog
Adult
age range
All Life Stages
All Life Stages
All Life Stages
All Life Stages
All Life Stages
All Life Stages
scent
Topical
No Scent
No Scent
Topical
No Scent
No Scent
form
Stick
Stick
Stick
Stick
Stick
Oil
volume
32 milliliters
8.04 milliliters
16.08 milliliters
18 milliliters
12.06 milliliters
active ingredients
fipronil and (S)-methoprene
Fipronil, (S)-methoprene, Pyriproxyfen
Fipronil, (S)-methoprene, Pyriproxyfen
Fipronil, Permethrin, Pyriproxyfen
Fipronil, (S)-methoprene, Pyriproxyfen
Methoprene, Fipronil

From the manufacturer

Smiling man playing fetch outside with healthy dog. Frontline Plus awarded Newsweek most trusted
Frontline Plus has been trusted by pet owners for over 20 years and kills fleas and chewing lice
Answers to frequently asked questions about Frontline flea and tick prevention and treatment plans

How to Apply FRONTLINE Plus for Dogs

Step one woman reading instructions on pack before applying flea and tick non prescription treatment

Step two woman holding applicator upright and away from her face before opening by snapping off tip

Step three prep dog for flea treatment application by using fingers to part fur so skin is visible

Step four place the open applicator to dogs skin and squeeze out all contents on dog

Read full instructions on packaging before use. Shown here: Size Large 45-88 lbs.

Use scissors to separate one blister. Hold applicator upright with foil side toward you and snap applicator tip off.

Part dog’s hair between shoulder blades until skin is visible.

Place applicator tip directly against exposed skin and apply entire contents directly to the skin. Do not apply on top of hair.

Pack of Frontline Plus for small dog breeds tratamiento de pulgas y garrapatas para perros pequenos Pack of Frontline Plus for medium dog breeds medicina para matar pulgas y garrapatas Pack of Frontline Plus for large dog breeds prevención de pulgas y garrapatas para perros grandes Pack of Frontline Plus for xl dog breeds control de pulgas y garrapatas para perros extra grandes Frontline Plus Cat
FRONTLINE Plus for Small Dogs FRONTLINE Plus for Medium Dogs FRONTLINE Plus for Large Dogs FRONTLINE Plus for X-Large Dogs FRONTLINE Plus for Cats
Customer Reviews
4.4 out of 5 stars
43,559
4.4 out of 5 stars
20,962
4.5 out of 5 stars
13,632
4.6 out of 5 stars
3,617
4.4 out of 5 stars
43,348
Recommended pet size 5 to 22 pounds 23 to 44 pounds 45 to 88 pounds 89 to 132 pounds Cats and kittens over 1.5 pounds
Kills adult fleas, flea eggs, and flea larvae
Kills ticks and chewing lice
Minimum age of pet for use Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Cats and kittens 8 weeks and older
Available sizes 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose
Do not use on cats Do not use on cats Do not use on cats Do not use on cats For use on cats only

From the brand

Product details

  • Product Dimensions ‏ : ‎ 1 x 5.75 x 4.5 inches; 0.01 ounces
  • Manufacturer recommended age ‏ : ‎ 1 month and up
  • Item model number ‏ : ‎ 72220
  • Date First Available ‏ : ‎ February 7, 2019
  • Manufacturer ‏ : ‎ Boehringer Ingelheim Animal Health
  • ASIN ‏ : ‎ B07NGXYVZZ
  • Customer Reviews:
    4.6 4.6 out of 5 stars 1,887 ratings

Product Description

Keep your dog protected with the #1 name in flea & tick protection*, FRONTLINE®. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years**— FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: *Data on file at Boehringer Ingelheim. **Data showing 20 years of trust in killing fleas and ticks is on file at Boehringer Ingelheim.

Looking for specific info?

Important information

Safety Information

KEEP OUT OF REACH OF CHILDREN. WARNING: PRECAUTIONARY STATEMENTS - HAZARDS TO HUMANS: WARNING. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid Contact with skin. Harmful if swallowed. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash clothing that may have come in contact with the product before reuse. HAZARDS TO DOMESTIC ANIMALS: For external use on dogs ONLY. Do not use on animals other than dogs. Do not use on dogs under 9 weeks of age or weighing less than 5 lbs. Individual sensitivities may occur after using ANY pesticide product. Dogs may experience some temporary irritation at the site of product application. If signs of sensitivity occur, bathe your dog with mild soap or shampoo and rinse with large amounts of water. If signs of sensitivity occur and persist, contact a veterinarian immediately. If your dog has an unusual reaction to the initial application, consult a veterinarian before repeating application. Certain medications can interact with pesticides. Consult a veterinarian before using on medicated, debilitated, aged, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products. Consult a veterinarian for guidance on use against Sarcoptes mites. This product is not a substitute for a prescribed heartworm preventative.nCall 1-888-637-4251, for assistance. PHYSICAL OR CHEMICAL HAZARDS: Do not allow this product to come in contact with an oxidizing agent, as a hazardous chemical reaction may occur Harmful if swallowed. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid contact with skin. Wear (specify appropriate protective eyewear such as goggles, face shield, or safety glasses). Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash contaminated clothing before reuse.

Directions

1. Part your dog's hair at the shoulder blades. 2. Apply content of applicator to the skin. 3. Repeat every 30 days for continuous protection.

Customer reviews

4.6 out of 5 stars
4.6 out of 5
1,887 global ratings
Crushed Box
4 Stars
Crushed Box
Product works fine, just wondering why a dinosaur sat on it before it arrived to me.
Thank you for your feedback
Sorry, there was an error
Sorry we couldn't load the review

Top reviews from the United States

Reviewed in the United States on November 12, 2023
Reviewed in the United States on October 5, 2023
One person found this helpful
Report
Reviewed in the United States on October 18, 2020
Reviewed in the United States on October 3, 2023
Reviewed in the United States on May 25, 2023
Reviewed in the United States on June 25, 2023
Reviewed in the United States on July 26, 2023