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Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 2-Month Supply

4.5 4.5 out of 5 stars 69,343 ratings
Amazon's Choice highlights highly rated, well-priced products available to ship immediately.
Amazon's Choice in Cat Flea Drops by Advantage

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2-Pack
Large Cat only

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About this item

  • Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application

Customer ratings by feature

Easy to use
4.3 4.3
Scent
3.8 3.8
Value for money
3.7 3.7

Customers usually keep this item

This product has fewer returns than average compared to similar products.

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From the manufacturer

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Cat lovers choose Advantage II Large Cat

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Kills and Protects

Kills adult fleas, flea larvae and flea eggs to break the flea life cycle and prevent further infestations.

Same-Day Effectiveness

Kills fleas on cats within 12 hours of application and continues to prevent infestations for a month.

Vet-Recommended

A leading brand in cat flea treatment and prevention, recommended for large cats over 9 lbs.

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About Advantage II

  • Easy-to-apply topical solution – no hard-to-swallow pills
  • 30-day protection
  • Fragrance-free, waterproof formula*

*24 hours after application

Easy Application - Step 1

Holding the tube upright and pointed away from you and your pet, remove the cap from the applicator tube. Turn the cap around, place it back on the tube and twist to break the seal.

Easy Application - Step 2

Part the hair on the neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin.**Do not get this product in your cat’s eye or allow your cat to ingest this product.

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Advantage II Large Cat Advantage XD Large Cat Advantage II Kitten Seresto Cat Advantage Cat Spray
Customer Reviews
4.5 out of 5 stars
69,343
4.3 out of 5 stars
1,261
4.4 out of 5 stars
7,823
4.5 out of 5 stars
38,193
4.0 out of 5 stars
724
Form Topical Drops Topical Drops Topical Drops Collar On-Pet Spray
Treatment Treatment + Prevention Treatment + Prevention Treatment + Prevention Treatment + Prevention Treatment
Application Frequency Monthly Every 2 Months Monthly Every 8 Months See Product Label
Kills Fleas?
Kills Ticks?
Starts to Kill Fleas Within 12 hours 30 mins - 4 hrs 12 hours 24 hours On Contact

Looking for specific info?

Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 1 x 4.38 x 4.75 inches; 0.66 ounces
  • Item model number ‏ : ‎ 86336677
  • Date First Available ‏ : ‎ September 1, 2014
  • Manufacturer ‏ : ‎ Elanco US Inc
  • ASIN ‏ : ‎ B00N7DEFH6
  • Country of Origin ‏ : ‎ Germany
  • Customer Reviews:
    4.5 4.5 out of 5 stars 69,343 ratings

Product Description

Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long.

Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia.

That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.

Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.

For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment.

Advantage II Large Cat is a trademark of Elanco or its affiliates.

Important information

Ingredients

Other

Directions

Application Instructions: 1. Use only on cats. 2. Hold applicator tube in an upright position. Pull cap off tube. 3. Turn the cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. 4. Part the hair at the base of the cat’s skull until skin is visible. 5. Evenly apply the entire contents of the Advantage II tube directly on the skin by squeezing the entirety of the contents in that one spot. Do not get this product in your cat’s eyes, or allow your cat to ingest this product.

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Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 2-Month Supply
Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 2-Month Supply
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Adventure Plus Triple Flea Protection for Cats – Spot on Flea & Tick Prevention for Cats between 5-9lbs – 4 Doses
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Price$32.48$34.98-21% $27.49
List:$34.99
-10% $51.98
List:$57.58
$32.48-6% $28.19
List:$29.99
Delivery
Get it as soon as Wednesday, Apr 3
Get it as soon as Wednesday, Apr 3
Customer Ratings
Easy to use
4.3
3.9
3.5
4.2
4.5
4.2
Scent
3.8
3.6
3.3
3.7
3.9
4.0
Value for money
3.7
3.4
3.2
3.5
4.0
3.6
Sold By
Amazon.com
Amazon.com
Apex Animal Health
Amazon.com
EntirelyPets
Amazon.com
target audience
Adult
Cat
Adult
Cats
age range
8 weeks and older
8 weeks and older
Kittens
8 weeks and older
All ages
8 weeks or older
scent
Unscented
Unscented
Unscented
Unscented
Topical
Unscented
form
Topical
Topical
Drops
Topical
Drops
volume
1.6 milliliters
1 milliliters
1.6 milliliters
6 milliliters
0.4 milliliters
active ingredients
Imidacloprid, Pyriproxyfen
Spinetoram
Imidacloprid, Pyriproxyfen
Pyriproxyfen
weight
0.04 pounds
0.71 ounces
0.05 pounds
0.06 ounces

Customer reviews

4.5 out of 5 stars
4.5 out of 5
69,343 global ratings

Customers say

Customers like the value, ease of use, side effects and quality of the pet pest control product. For example, they mention it works great, it comes with thorough instructions and that it's worth buying for cats. That said, opinions are mixed on irritation, effect on cat, and smell.

AI-generated from the text of customer reviews

4,611 customers mention3,256 positive1,355 negative

Customers like the quality of the pet pest control product. They mention that it works well, is effective, and easy to apply. Some say that it starts working after about a day and that it's great at killing and repelling fleas. Overall, most are satisfied with the product's quality and performance.

"PROS: works well, appropriate for large cats, easy application, ability to buy in bulk..." Read more

"...However, it's absolutely worth it. It works very well and I've always felt that my cats not suffering is more important than the price tag...." Read more

"...The box was incredibly damaged but the product itself was fine, so I'm not worried about a return or refund or anything, and I'm not going to dock a..." Read more

"Love it! Fast & effective!" Read more

2,236 customers mention1,685 positive551 negative

Customers like the flea control of the pet pest control. They mention that it works well, keeps fleas away, and eradicates the problem. Some say that the product is the only product that takes out mutant Texas flea. Overall, most are satisfied with the product's ability to provide total flea protection.

"...My cats didn't like it, but it was safer and easier than flea baths!..." Read more

"I gave this to all 4 of my cats and it got rid of the fleas completely and so far they haven’t come back and didn’t make my cats sick." Read more

"...I compared and chose this. It worked! No fleas, BUT in November, I discovered a attached tick to our cat Sam...." Read more

"...is cheaper but in order for frontline to work, the fleas have to bite the animals. This product does not require them to be bitten...." Read more

1,536 customers mention1,111 positive425 negative

Customers like the value of the pet pest control. They say it works great and is good value for the price. Some customers also mention that the product is very cheap.

"Best price deal" Read more

"...The stuff really works and it was worth the price!" Read more

"...CONS: expensive, sometimes applicator breaks, stinky smell!..." Read more

"Fantastic price, works well enough as part of a flea maintenance program for your cat..." Read more

592 customers mention561 positive31 negative

Customers find the pet pest control product easy to use. They say the instructions are simple and easy to follow. They appreciate the thorough instructions that come with the product.

"...The product arrived quickly, and came with thorough instructions, which I skimmed. The medication comes in a tiny tube incased in a foil packet...." Read more

"...It's even easy to use on our most skiddish cat. She barely notices we are doing it. My only complaint is I wish it would dry faster...." Read more

"...It is easy to apply." Read more

"It's not hard to apply by themselves however multiple cats need to be separated and nailed at the same time ish...." Read more

287 customers mention250 positive37 negative

Customers like the side effects of the pet pest control product. They say they have experienced no ill effects, allergic reactions, or negative side effects. They also mention that the medication works great and does not harm the animals. Customers also say that the cats are happy, healthy, and flea-free.

"I use this monthly and appears to work. No side effects from my cat are noticeable. No fleas." Read more

"This worked well for my 19 pound kitty with no noticeable side effects" Read more

"...They did not have any reactions to the medication and it started working after about a day...." Read more

"...So far, no bad effects, and the best effects since I have been using this product, is no flea infestations...." Read more

534 customers mention316 positive218 negative

Customers are mixed about the irritation of the pet pest control product. Some mention that within 24 hours the itching and scratching was significantly diminished, while others say that it made a difference but their cat had a bit of skin irritation where the product was applied.

"...For once in little over a year, my cats are FINALLY comfortable. And I am so happy I bought this...." Read more

"...Maybe this stuff burns or irritates her skin?" Read more

"...At least they're not scratching as much, and the sores around their necks are actually starting to scab over which is so wonderful...." Read more

"...I applied the application and within a day I noticed my kitties weren't scratching and b/c of the fleas one of my cats got dermatitis & started..." Read more

311 customers mention205 positive106 negative

Customers are mixed about the effect of the pet pest control. Some mention that it makes their cats happy, healthy, and flea-free, while others say that it made their cats very sick and lethargic after application.

"...Pills or liquid are not cats favorite. Happy cats, no bleeding scratches. I shop around, but mainly wait fir these to go on sale. Great buy...." Read more

"...kills fleas for the first two weeks and then just creates a nasty environment on my cats fur for them live on for the last two weeks which is why I..." Read more

"...30 days later she is normal again and very active and happy! Both my cats are so happy and I'm using this each month as their flea prevention!..." Read more

"...a small trace of fleas and it easily applied and helped the problem almost immediately." Read more

240 customers mention118 positive122 negative

Customers are mixed about the smell of the pet pest control. Some mention that it has no evident smell, while others say that it does smell a little bit funky. Some say that their cats eventually learn the scent and may shy away from it.

"Easy to apply. No smell. My cat quit scratching by the next day. Down side is you have to reapply every month...." Read more

"...CONS: expensive, sometimes applicator breaks, stinky smell!..." Read more

"...There is no evident smell though. We felt safer using external flea medication on our cats and noticed no adverse side effects...." Read more

"...'s “fragrance-free”, but I have always found that there is a slight “chemically” smell to it. The smell goes away once it dries...." Read more

Saving Grace
5 Stars
Saving Grace
I tried multiple over the shelf flea protectant. Powder, spray, nothing was working. I gave in and tried this product and within weeks they were gone. Keep in mind I was vacuuming my carpet twice a day as well as combing through my 3 cats twice a day. But once the medicine gets in their blood stream, the fleas don’t want them anymore. Don’t be discouraged after she a few on them a day or 2 after you first apply, it takes time. But 1000% worth it.
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Top reviews from the United States

Reviewed in the United States on July 24, 2016
Size: 6-PackStyle: Large Cat onlyVerified Purchase
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5.0 out of 5 stars REVIEW OF ADVANTAGE II LARGE CAT FLEA CONTROL
Reviewed in the United States on July 24, 2016
PROS: works well, appropriate for large cats, easy application, ability to buy in bulk
CONS: expensive, sometimes applicator breaks, stinky smell!

I first purchased this product in August 2015, Again in Janurary 2016, and I just purchased this again (July 2016). I purchased this product to help control fleas on my two cats, one of which is an indoor/outdoor cat. The neighborhood I live in has terrible fleas, so using flea medication is essential.

The product arrived quickly, and came with thorough instructions, which I skimmed. The medication comes in a tiny tube incased in a foil packet. I opened the packet, and took out the tube. You break the seal on the tube by inverting the cap and puncturing the seal. I did this and accidentally twisted, causing the point on the top of the lid to become lodged in the opening of the tube. This was stressful because each treatment is so expensive. I realized, however, that I could fish out the point with some tweezers and still use the product! I then pinned my cat down and applied the product to the back of their neck. While I did see a decrease in fleas, I still saw several. I increased application to once every two weeks, and added baths and flea combing to the regime. Eventually, I was able to apply only once a month. During the summer the flea population seems to increase, which also coincided with my adoption of a second cat. I noticed the cat came in with fleas and I applied this medication, but it didn't seem to do much. I then woke up one morning with about 30 flea bites covering my lower legs and feet! I was horrified, and I knew it was time to get serious!

After a bit of research I realized apart of why the medication may have been ineffective previously was that I wasn't applying it correctly (ha! Thats what i get for skimming!) Rereading instructions, I realized that I need to part my cats fur and try to make skin contact with the medication. I also learned that if my cats lick it it will taste bitter, discouraging licking behaviors of the medication. I'm going to include a few steps I took to control fleas in my house, unrelated to this product, but I think it might be useful! Scroll down to my conclusion if uninterested :) Anyways, so my cats hate baths (they were both rescued and are older so its hard to introduce new behaviors, I mean, I'm no jackson galaxy) For this reason flea baths always stressed me out and I was worried about my cats catching a cold or licking the flea shampoo and getting sick.Instead of bathing my cats, I gave them a pill that will kill all the fleas on them within 6 hours( https://www.amazon.com/Novartis-Capstar-Flea-Tablets-Count/dp/B005Z6UL1M/ref=sr_1_2?ie=UTF8&qid=1469319334&sr=8-2&keywords=flea+killer+pill). Using this pill in conjunction with this treatment, was a life saver! The next thing I did was give my pets a dry, diatomaceous earth bath. If you choose to do this with your cats, make sure you use food grade DE. DE is a great natural alternative for flea control, but the dust can be damaging to yourself and your cats! To prevent this, I wore a bandana around my mouth, and I stuck a comfy cone on my cat ( https://www.amazon.com/Comfy-Cone-E-Collar-Large-Black/dp/B000XY7CKE/ref=sr_1_1?ie=UTF8&qid=1469319818&sr=8-1&keywords=comfy+cone). My cats didn't like it, but it was safer and easier than flea baths! I also put some apple cider vinegar diluted with water in a spray bottle, and I sprayed down my cats. They hated this, but I think it maybe helped the fleas? It also reduced dust from the DE.

CONCLUSION: I think that all cat owners should use this product on their cats, even if their cats are indoor cats. an inch of prevention is worth a pound of solution, and this is especially true for fleas. Make sure to treat your cats regularly and make sure you apply it correctly!

included some photos of my happy flea free cats :)
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Reviewed in the United States on March 5, 2024
Size: 6-PackStyle: Large Cat onlyVerified Purchase
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Reviewed in the United States on March 13, 2024
Size: 4-PackStyle: Large Cat onlyVerified Purchase
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Reviewed in the United States on December 11, 2023
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Reviewed in the United States on September 4, 2016
Size: 6-PackStyle: Large Cat onlyVerified Purchase
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5.0 out of 5 stars ABSOLUTE GODSEND
Reviewed in the United States on September 4, 2016
Back in March of 2015 I moved from Northwest Ohio to southeast Kentucky, and with me I brought two cats which my cousin had given me the night before my move. He failed to tell me what he had been using as a flea prevention since his cats were indoor-outdoor and I forgot to ask. In fact, I forgot fleas even existed until I started getting bit by them and the cats started occupying their time with scratching.

For the past year I have been battling this infestation and clearly with no luck. I tried cheap flea drops, flea collars, dusting the carpets with boric acid and then later Diatomaceous Earth when I realized Boric acid wasn't safe for the cats. I tried bathing the cats with dawn every week and it just didn't work. I felt the Diatomaceous Earth only agitated the fleas and made them bite more.

I am a self-employed freelance artist and so money is usually tight. What doesn't go back into my work goes into food and litter for the cats and there's usually not enough left over for big name brand flea medication, which is why I tried cheap stuff up till now.

My friend suggested I try Adam's Flea Shampoo on the cats since it worked so well for her dog. I did, and it gave them temporary relief but it is not a preventative and I didn't buy it thinking it was - I just wanted another tool in my box to try and battle these fleas.

Fastforward a month; the fleas are still here, my bag of DE is almost empty, vacuuming hasn't helped a whole lot because the cats are still infested and I am starting to react badly to the flea bites, even getting really itchy sores. I finally have enough leftover in my bank account to get some actual medication and so I buy this after doing a little bit of research.

I bathed the cats with the Adams flea shampoo the night before using the medicine and applied the drops to both of my cats early in the morning the next day - yesterday. This morning I checked the cat which had the infestation worse - whenever I combed him he would usually have PILES of live fleas squirming on the comb. I ran the comb through his fur today, starting with his back which is usually where the fleas would seem to congregate.

Nothing.

I thought maybe I just hadn't hit their spot that time so I ran it down the entire length of his back.

Nothing.

I figured there had to be something wrong so I combed his neck and withers and still the comb was clean.

In disbelief I flipped him over and combed his belly and thighs and still NOTHING. Just one day after applying the drops, both of my cats are flea free.

My house isn't still, so I will have to keep treating it, but it should be so much easier now that the cats are free from those pests.

I am in such utter disbelief that I've been checking the cats constantly all day just to be sure what I was seeing was true. For once in little over a year, my cats are FINALLY comfortable. And I am so happy I bought this.

i am a little confused, though, about Amazon's packing strategy. When I opened the box it was shipped in, the box the drops were in was open. Now this is the type of box that you have to tear the lid open from its perforated line, so there's no way it could've opened by itself in transit.

The box was incredibly damaged but the product itself was fine, so I'm not worried about a return or refund or anything, and I'm not going to dock a star because of it, because the product itself deserves 5 stars alone.

The picture shows exactly how it was in the box.

I definitely recommend Advantage II and I won't buy anything else until or unless the fleas start bevoming immune to it like they did Frontline.
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