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FRONTLINE Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs., 8 Treatments

4.4 4.4 out of 5 stars 21,076 ratings
Amazon's Choice highlights highly rated, well-priced products available to ship immediately.
Amazon's Choice in Dog Flea Drops by Frontline
$89.98 with 14 percent savings $11.25 per Count
List Price: $104.99

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8 count
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Purchase options and add-ons

Brand Frontline
Item Form Stick
Scent Topical
Age Range (Description) All Life Stages
Item Weight 2.4 Ounces
Active Ingredients fipronil and (S)-methoprene
Item Volume 6 Milliliters
Target Species Medium Dog, 23-44 Pounds
Allergen Information Gluten Free
Dog Breed Size Medium

About this item

  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease.
  • Break the flea life cycle with FRONTLINE Plus. Specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control.
  • Trusted by pet owners for over 20 years**, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days.
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products.
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations.
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus.

Additional Details

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Customer ratings by feature

Easy to use
4.0 4.0
Easy to remove
3.5 3.5
Scent
3.5 3.5
Value for money
3.1 3.1
See all reviews

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FRONTLINE Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs., 8 Treatments
$89.98 ($11.25/Count)
Get it as soon as Monday, May 13
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FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs., 8 Treatments
$96.98 ($12.12/Count)
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FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs., 3 Treatments
$30.93 ($10.31/Count)
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From the brand

Previous page
  2. Frontline brand products logo. Protect your dog or cat with Frontline Plus flea and tick prevention

    THE #1 NAME IN FLEA & TICK PROTECTION*

    FRONTLINE Brand Products are effective topical solutions designed to help protect dogs and cats from fleas and ticks. FRONTLINE Plus and FRONTLINE Gold have formulas for dogs or cats. FRONTLINE Shield, with added mosquito repellency, is for dogs only.

  3. Frontline Plus for Dogs and Puppies has been trusted by pet owners for over twenty years
    Frontline Plus flea and tick medicine for small dogs six topical nonprescription applicators pack
    Frontline Plus flea and tick medicine for medium dogs six topical nonprescription applicators pack
    Frontline Plus flea and tick medicine for large dogs pack of six topical nonprescription applicators

    FRONTLINE Plus for Dogs

    Visit the Store

  4. Frontline Shield is formulated to repel ticks and mosquitoes. repelente de mosquitos para perros
    Frontline Shield flea and tick treatment and mosquito repellent for small dogs six month pack
    Frontline Shield flea and tick treatment and mosquito repellent for medium dogs six month pack
    Frontline Shield flea and tick treatment and mosquito repellent for large dogs six month pack

    FRONTLINE Shield for Dogs

    Visit the Store

  5. Frontline Plus for Cats and Kittens has been trusted by pet owners for over twenty years
    Frontline Plus flea and tick monthly prevention topical for cats and kittens three doses
    Frontline Plus flea and tick monthly prevention topical for cats and kittens six doses
    Frontline Plus flea and tick monthly prevention topical for cats and kittens eight doses

    FRONTLINE Plus for Cats

    Visit the Store

  6. Frontline comes in an easy to use applicator. Use spring summer fall winter to kill fleas and ticks
    Frontline Gold flea and tick treatment for small dogs six month supply pack
    Frontline Gold flea and tick treatment for medium dogs six month supply pack
    Frontline Gold flea and tick treatment for large dogs six month supply pack

    FRONTLINE Gold for Dogs

    Visit the Store

  7. Frontline comes in an easy to use applicator. Apply during all seasons to prevent fleas and ticks
    Frontline Gold for Cats three month supply pack. suministro de tratamiento para tres meses
    Frontline Gold for Cats six month supply pack. suministro de tratamiento para seis meses
    Frontline Gold flea and tick protection for cats and kittens

    FRONTLINE Gold for Cats

    Visit the Store

  8. Frontline brands break the flea life cycle by eradicating adult fleas eggs and larvae. Treat monthly

  9. What is FRONTLINE?

    FRONTLINE Brand Products are effective, easy-to-apply topical flea & tick preventives. FRONTLINE Plus and FRONTLINE Gold have formulas for dogs or cats. FRONTLINE Shield is for dogs only. All FRONTLINE Brand Products feature waterproof formulas that last a full 30 days.

    Why should I protect my dog or cat from fleas & ticks?

    Fleas & ticks are a year-round threat. FRONTLINE Brand Products help protect dogs or cats from these pests and monthly use can help prevent infestations.

Next page

From the manufacturer

Smiling man playing fetch outside with healthy dog. Frontline Plus awarded Newsweek most trusted
Frontline Plus has been trusted by pet owners for over 20 years and kills fleas and chewing lice
Answers to frequently asked questions about Frontline flea and tick prevention and treatment plans

How to Apply FRONTLINE Plus for Dogs

Step one woman reading instructions on pack before applying flea and tick non prescription treatment

Step two woman holding applicator upright and away from her face before opening by snapping off tip

Step three prep dog for flea treatment application by using fingers to part fur so skin is visible

Step four place the open applicator to dogs skin and squeeze out all contents on dog

Read full instructions on packaging before use. Shown here: Size Large 45-88 lbs.

Use scissors to separate one blister. Hold applicator upright with foil side toward you and snap applicator tip off.

Part dog’s hair between shoulder blades until skin is visible.

Place applicator tip directly against exposed skin and apply entire contents directly to the skin. Do not apply on top of hair.

Pack of Frontline Plus for small dog breeds tratamiento de pulgas y garrapatas para perros pequenos Pack of Frontline Plus for medium dog breeds medicina para matar pulgas y garrapatas Pack of Frontline Plus for large dog breeds prevención de pulgas y garrapatas para perros grandes Pack of Frontline Plus for xl dog breeds control de pulgas y garrapatas para perros extra grandes Frontline Plus Cat
FRONTLINE Plus for Small Dogs FRONTLINE Plus for Medium Dogs FRONTLINE Plus for Large Dogs FRONTLINE Plus for X-Large Dogs FRONTLINE Plus for Cats
Customer Reviews
4.4 out of 5 stars
80,746
4.4 out of 5 stars
21,076
4.4 out of 5 stars
80,746
4.5 out of 5 stars
13,801
4.3 out of 5 stars
43,619
Price $65.45 $69.00 $69.00 $67.14 $69.00
Recommended pet size 5 to 22 pounds 23 to 44 pounds 45 to 88 pounds 89 to 132 pounds Cats and kittens over 1.5 pounds
Kills adult fleas, flea eggs, and flea larvae ✓ ✓ ✓ ✓ ✓
Kills ticks and chewing lice ✓ ✓ ✓ ✓ ✓
Minimum age of pet for use Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Cats and kittens 8 weeks and older
Available sizes 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose
Do not use on cats Do not use on cats Do not use on cats Do not use on cats For use on cats only

Product information

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FRONTLINE

FRONTLINE Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs., 8 Treatments

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Product details

  • Product Dimensions ‏ : ‎ 0.63 x 5.75 x 4.5 inches; 2.4 ounces
  • Manufacturer recommended age ‏ : ‎ 1 month and up
  • Item model number ‏ : ‎ 72218
  • Date First Available ‏ : ‎ February 7, 2019
  • Manufacturer ‏ : ‎ Boehringer Ingelheim Animal Health
  • ASIN ‏ : ‎ B07NGRSVLF
  • Country of Origin ‏ : ‎ France
  • Customer Reviews:
    4.4 4.4 out of 5 stars 21,076 ratings

Looking for specific info?

Product Description

Keep your dog protected with the #1 name in flea & tick protection*, FRONTLINE®. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years**— FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: *Data on file at Boehringer Ingelheim. **Data showing 20 years of trust in killing fleas and ticks is on file at Boehringer Ingelheim.

Top Brand: Frontline

Highly Rated
100K+ customers rate items from this brand highly
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100K+ orders for this brand in past 3 months
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Important information

Safety Information

KEEP OUT OF REACH OF CHILDREN. WARNING: PRECAUTIONARY STATEMENTS - HAZARDS TO HUMANS: WARNING. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid Contact with skin. Harmful if swallowed. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash clothing that may have come in contact with the product before reuse. HAZARDS TO DOMESTIC ANIMALS: For external use on dogs ONLY. Do not use on animals other than dogs. Do not use on dogs under 9 weeks of age or weighing less than 5 lbs. Individual sensitivities may occur after using ANY pesticide product. Dogs may experience some temporary irritation at the site of product application. If signs of sensitivity occur, bathe your dog with mild soap or shampoo and rinse with large amounts of water. If signs of sensitivity occur and persist, contact a veterinarian immediately. If your dog has an unusual reaction to the initial application, consult a veterinarian before repeating application. Certain medications can interact with pesticides. Consult a veterinarian before using on medicated, debilitated, aged, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products. Consult a veterinarian for guidance on use against Sarcoptes mites. This product is not a substitute for a prescribed heartworm preventative.nCall 1-888-637-4251, for assistance. PHYSICAL OR CHEMICAL HAZARDS: Do not allow this product to come in contact with an oxidizing agent, as a hazardous chemical reaction may occur Harmful if swallowed. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid contact with skin. Wear (specify appropriate protective eyewear such as goggles, face shield, or safety glasses). Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash contaminated clothing before reuse.

Directions

1. Part your dog's hair at the shoulder blades. 2. Apply content of applicator to the skin. 3. Repeat every 30 days for continuous protection.

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FRONTLINE Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs., 8 Treatments
FRONTLINE Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs., 8 Treatments
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Price-14% $89.98
List: $104.99		$94.99-14% $81.56
Typical: $94.99		-15% $70.53
List: $82.99		$82.98-15% $39.93
List: $46.99
Delivery
Get it as soon as Monday, May 13
Get it May 10 - 14
Get it as soon as Tuesday, May 14
Get it as soon as Sunday, May 12
Get it as soon as Sunday, May 12
Get it as soon as Sunday, May 12
Customer Ratings
4.44.4 out of 5 stars21,076
4.34.3 out of 5 stars149
4.54.5 out of 5 stars567
4.24.2 out of 5 stars443
4.34.3 out of 5 stars1,393
4.44.4 out of 5 stars387
Easy to use
4.0
3.9
4.4
4.2
4.0
4.2
Scent
3.5
3.5
4.4
3.5
4.0
3.3
Value for money
3.1
2.5
3.8
3.0
3.2
3.0
Flavor
—
—
2.4
4.8
2.9
3.0
Sold By
Amazon.com
Petco
Amazon.com
Amazon.com
Amazon.com
Amazon.com
target audience
Dogs
Adult
Adult
Dog
Dog
Dog
age range
All Life Stages
All Life Stages
All Life Stages
All Life Stages
All Life Stages
All Life Stages
scent
Topical
No Scent
No Scent
Topical
Topical
Topical
form
Stick
Stick
Stick
Stick
Stick
Stick
volume
6 milliliters
8.04 milliliters
16.08 milliliters
3 milliliters
24 milliliters
18 milliliters
active ingredients
fipronil and (S)-methoprene
Fipronil, (S)-methoprene, Pyriproxyfen
Fipronil, (S)-methoprene, Pyriproxyfen
Fipronil, Permethrin, Pyriproxyfen
Fipronil, Permethrin, Pyriproxyfen
Fipronil, Permethrin, Pyriproxyfen
weight
2.4 ounces
—
0.1 pounds
0.09 pounds
0.81 ounces
—

Customer reviews

4.4 out of 5 stars
4.4 out of 5
21,076 global ratings

Customers say

Customers like the value, quality and ease of use of the pet pest control product. For example, they mention it's a great value for the product, saves putting 2 different boxes together and the instructions are clear. That said, opinions are mixed on performance, fleas and side effects.

AI-generated from the text of customer reviews

415 customers mention307 positive108 negative

Customers like the value of the pet pest control. They say it saves them money as they don't have to buy 2 different boxes.

"Product works great, used for years, my dog never had fleas. Price was cheaper than buying from the Vet!!" Read more

"...Ticks are especially heavy here as well as fleas!! Good price also for this product!!" Read more

"...It’s a little pricey, but my dogs health is invaluable." Read more

"...Yay! Second dogs bath is tomorrow. Great product and it’s worth the extra money!" Read more

317 customers mention267 positive50 negative

Customers like the quality of the pet pest control. They say it's a reliable product that keeps their dog free of flea bites. They also say the medicine is high quality and has a good reputation. Some customers however, report that the product seems weak.

"The product is very good although a little strong for the recommended dose!..." Read more

"For what it is, this is a fine product...." Read more

"...For safety, Frontline Plus can't be beat! It's even safe to use on pregnant and lactating dogs...." Read more

"Great product and great service" Read more

119 customers mention112 positive7 negative

Customers find the pet pest control easy to use. They say the instructions are clear and easy to understand. They also say the product is trouble-free and effective. Customers also appreciate the clear plastic vials and say it's not hard to apply.

"I love that I can order and receive package from my home. Easy to apply on my dog. Price is right too." Read more

"This product was recommended by my daughters vet. The application is easy, just put some drops on the dogs back by the neck and by the butt, that's..." Read more

"...In those instances this works just fine. It easy to use and last for 1 month. My dog has never had any infestations while using it" Read more

"...I also like the easy snap and apply set up on the applicator -- very easy to use.I DON'T like the packaging...." Read more

95 customers mention70 positive25 negative

Customers like the ticks. For example, they say it's effective against ticks, and has helped keep their dogs tick-free. Some say it prevents more ticks from latching on.

"We tried less expensive options, but this works best at deterring ticks." Read more

"...And I like knowing that Frontline can kill the tick on contact with his skin / fur rather than having to wait for it to bite him...." Read more

"...A week after applying they were covered in ticks, and 2 weeks after that I keep finding them on them still. Very disappointed." Read more

"No fleas, no ticks !! I have a heavy coated collie on cape cod which is tick city and this year was extra bad ….. I got ticks my dog had none" Read more

922 customers mention417 positive505 negative

Customers are mixed about the performance of the pet pest control. Some mention it works very well, while others say it's ineffective and does little to nothing to kill or repel fleas.

"...I apply it about every 3 weeks. I'm convinced it does very little to nothing to kill or repell fleas...." Read more

"Product works great, used for years, my dog never had fleas. Price was cheaper than buying from the Vet!!" Read more

"...But it gas not been as effective as advertised. Probably not suited for the tropical climate I'm in." Read more

"...had an issue with any of my dogs with fleas or ticks, the product clearly works well...." Read more

459 customers mention264 positive195 negative

Customers are mixed about the fleas. Some mention that they use Frontline and never have any issue with flea. They say it helps with flees for a month and kills flea and other parasites. Others however, say that they still have flea on their dog daily and that it did nothing to prevent flea infestation.

"Product works great, used for years, my dog never had fleas. Price was cheaper than buying from the Vet!!" Read more

"Used this twice and as of today, she still has fleas!I’m afraid to put any more on her, it hasn’t even been a month , it’s too dangerous...." Read more

"...My dog is free of live fleas, he still has some larvae but I think those are dying off because i still don’t see any babies when I check here and..." Read more

"...Its now 9 days post application and she still has fleas and tiny ticks...." Read more

111 customers mention73 positive38 negative

Customers are mixed about the side effects of the pet pest control. Some mention that it doesn't make their skin irritate, and it doesn’t make them sick. However, others say that it makes their dogs itch like crazy, and has an allergic reaction.

"It definitely does the job and it doesn’t irritate my dog either" Read more

"Frontline is by far the best preventative and reactive flea treatment I've used outside of a prescription...." Read more

"...she started to have dry flaky skin all over and also showed signs of fleas by scratching...." Read more

"...There have been no adverse effects on the animals either. We also see no sign of fleas remaining on the dogs at all...." Read more

43 customers mention14 positive29 negative

Customers are mixed about the durability of the pet pest control product. Some mention it's easy to use and lasts all month, while others say it wears out a bit near the end of the monthly application. Some say it didn't stop the tick life cycle and that it permanently damages both fabric and leather.

"...This used to be the best thing but now it seems like I'm lucky if it lasts 3 weeks...." Read more

"...in less than 30 days they came back in about 10 days so this product doesn't last there are other oral substitutions that I'm going to have to try." Read more

"I like the fact that you can administer it on a monthly basis" Read more

"...I've noticed that in the middle of summer, Frontline plus seems to wear out a bit near the end of the monthly cycle, so I recommend going every..." Read more

Flea control
5 Stars
Flea control
This is the only flea treatment I need for my dog and home. Makes a happy dog every time to not be bothered with fleas
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Top reviews from the United States

Ron
5.0 out of 5 stars No fleas now
Reviewed in the United States on April 21, 2024
Size: 6 countVerified Purchase
Product works great, used for years, my dog never had fleas. Price was cheaper than buying from the Vet!!
Helpful
 Report
Grlsjstwanna
5.0 out of 5 stars Doesn’t work
Reviewed in the United States on September 3, 2023
Size: 8 countVerified Purchase
Used this twice and as of today, she still has fleas!
I’m afraid to put any more on her, it hasn’t even been a month , it’s too dangerous.
She’s a small long haired Chihuahua, she got the fleas from a friend’s cat while we were visiting, we were only there for a few hours.
This is crazy, we’ve never had this problem.
It’s bath time, I won’t be using this stuff again.
5 people found this helpful
Helpful
 Report
JV Blanco, MArch I, MHsPv, BArch
5.0 out of 5 stars Great flea and tick remedy for dogs: reliable, effective and easy to use
Reviewed in the United States on February 2, 2024
Size: 3 countVerified Purchase
I’ve been utilizing this product on my Frenchies for years. The one qualm I have about the product is its application. It’s a liquid or an oil substance that dispenses from a plastic “pen” that I sometimes feel might harm my dog if he tries to lick it. It’s never actually happened so my paranoia is yet unjustified. The oil is applied length wise from the base of the neck to about 3/4 of the way down the dogs spine. I’ve never had an issue with any of my dogs with fleas or ticks, the product clearly works well. I will continue to utilize this product loyally and with trust. It’s a little pricey, but my dogs health is invaluable.
3 people found this helpful
Helpful
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Sylvia Whittum
4.0 out of 5 stars This product seems to work well.
Reviewed in the United States on April 7, 2024
Size: 3 countVerified Purchase
We live in a heavily wooded area with open fields in New Hampshire. Ticks are especially heavy here as well as fleas!! Good price also for this product!!
One person found this helpful
Helpful
 Report
Ash Carlton
5.0 out of 5 stars No more fleas.
Reviewed in the United States on April 15, 2024
Size: 3 countVerified Purchase
This stuff works great. I use it on both of my dogs.
Helpful
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WINGMAN
5.0 out of 5 stars Great product
Reviewed in the United States on March 28, 2024
Size: 6 countVerified Purchase
It definitely does the job and it doesn’t irritate my dog either
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wesley ross Addington
5.0 out of 5 stars Worth the price
Reviewed in the United States on May 3, 2024
Size: 3 countVerified Purchase
Very good
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Dottie
4.0 out of 5 stars Cost!
Reviewed in the United States on April 28, 2024
Size: 3 countVerified Purchase
Last year we had to schedule an app’t with the vet, have “routine” labs, and each tab cost $50. Total bill? $450. This year a new vet, who understands we are in our 80’s and 90’’s and our dog is a geriatric 14 years old! (normal lifespan for this breed … 6-8)
Years!)
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