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FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs., 3 Treatments

4.4 4.4 out of 5 stars 27,304 ratings
Amazon's Choice highlights highly rated, well-priced products available to ship immediately.
Amazon's Choice in Dog Flea Drops by Frontline

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About this item

  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease.
  • Break the flea life cycle with FRONTLINE Plus. Specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control.
  • Trusted by pet owners for over 20 years**, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days.
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products.
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations.
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus.

Customer ratings by feature

Easy to use
3.9 3.9
Scent
3.5 3.5
Comfort
3.3 3.3
Easy to remove
3.1 3.1

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FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs., 3 Treatments
FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs., 3 Treatments
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Price-20% $39.98
List:$49.99
-13% $54.99
List:$62.99
$94.99$14.99-10% $17.99
List:$19.99
-18% $40.99
List:$49.99
Delivery
Get it as soon as Monday, Apr 1
Get it as soon as Monday, Apr 1
Get it as soon as Monday, Apr 1
Get it as soon as Monday, Apr 1
Get it as soon as Monday, Apr 1
Customer Ratings
Easy to use
3.9
4.4
4.4
4.0
3.3
4.2
Value for money
3.0
3.8
3.8
3.1
1.7
3.4
Flavor
2.6
2.6
3.3
2.1
3.0
Comfort
3.3
4.6
4.6
2.4
Scent
3.5
4.4
4.4
Sold By
Amazon.com
Amazon.com
Amazon.com
kingmo Pet
PETIQ
Amazon.com
target audience
Dogs
Adult
Adult
Dog
Dog, Dog, Dog, Dog, Dog
Dogs
age range
All Life Stages
All Life Stages
All Life Stages
All Life Stages
All Life Stages
All Life Stages
scent
Unscented
No Scent
No Scent
Unscented
form
Stick
Stick
Stick
Drops
Drops
Stick
volume
339 milliliters
8.04 milliliters
16.08 milliliters
302.4 milliliters
active ingredients
fipronil and (S)-methoprene
Fipronil, (S)-methoprene, Pyriproxyfen
Fipronil, (S)-methoprene, Pyriproxyfen
Fipronil 9.8%, (S)-methoprene 8.8%, OTHER INGREDIENTS 81.4%, TOTAL 100.0%
Fipronil, Cyphenothrin, (S)-methoprene
fipronil and (S)-methoprene

From the brand


From the manufacturer

Smiling man playing fetch outside with healthy dog. Frontline Plus awarded Newsweek most trusted
Frontline Plus has been trusted by pet owners for over 20 years and kills fleas and chewing lice
Answers to frequently asked questions about Frontline flea and tick prevention and treatment plans

How to Apply FRONTLINE Plus for Dogs

Step one woman reading instructions on pack before applying flea and tick non prescription treatment

Step two woman holding applicator upright and away from her face before opening by snapping off tip

Step three prep dog for flea treatment application by using fingers to part fur so skin is visible

Step four place the open applicator to dogs skin and squeeze out all contents on dog

Read full instructions on packaging before use. Shown here: Size Large 45-88 lbs.

Use scissors to separate one blister. Hold applicator upright with foil side toward you and snap applicator tip off.

Part dog’s hair between shoulder blades until skin is visible.

Place applicator tip directly against exposed skin and apply entire contents directly to the skin. Do not apply on top of hair.

Pack of Frontline Plus for small dog breeds tratamiento de pulgas y garrapatas para perros pequenos Pack of Frontline Plus for medium dog breeds medicina para matar pulgas y garrapatas Pack of Frontline Plus for large dog breeds prevención de pulgas y garrapatas para perros grandes Pack of Frontline Plus for xl dog breeds control de pulgas y garrapatas para perros extra grandes Frontline Plus Cat
FRONTLINE Plus for Small Dogs FRONTLINE Plus for Medium Dogs FRONTLINE Plus for Large Dogs FRONTLINE Plus for X-Large Dogs FRONTLINE Plus for Cats
Customer Reviews
4.4 out of 5 stars
43,559
4.4 out of 5 stars
20,962
4.5 out of 5 stars
13,632
4.6 out of 5 stars
3,617
4.4 out of 5 stars
43,348
Recommended pet size 5 to 22 pounds 23 to 44 pounds 45 to 88 pounds 89 to 132 pounds Cats and kittens over 1.5 pounds
Kills adult fleas, flea eggs, and flea larvae
Kills ticks and chewing lice
Minimum age of pet for use Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Cats and kittens 8 weeks and older
Available sizes 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose
Do not use on cats Do not use on cats Do not use on cats Do not use on cats For use on cats only

Product guides and documents

Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 5.75 x 0.75 x 4.5 inches; 1.6 ounces
  • Manufacturer recommended age ‏ : ‎ 1 month and up
  • Item model number ‏ : ‎ 72219
  • Department ‏ : ‎ Insect Control
  • Date First Available ‏ : ‎ September 2, 2004
  • Manufacturer ‏ : ‎ Boehringer Ingelheim Animal Health
  • ASIN ‏ : ‎ B0002J1FOE
  • Country of Origin ‏ : ‎ Germany
  • Customer Reviews:
    4.4 4.4 out of 5 stars 27,304 ratings

Looking for specific info?

Product Description

Keep your dog protected with the #1 name in flea & tick protection*, FRONTLINE®. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years**— FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: *Data on file at Boehringer Ingelheim. **Data showing 20 years of trust in killing fleas and ticks is on file at Boehringer Ingelheim.

Important information

Safety Information

KEEP OUT OF REACH OF CHILDREN. WARNING: PRECAUTIONARY STATEMENTS - HAZARDS TO HUMANS: WARNING. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid Contact with skin. Harmful if swallowed. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash clothing that may have come in contact with the product before reuse. HAZARDS TO DOMESTIC ANIMALS: For external use on dogs ONLY. Do not use on animals other than dogs. Do not use on dogs under 9 weeks of age or weighing less than 5 lbs. Individual sensitivities may occur after using ANY pesticide product. Dogs may experience some temporary irritation at the site of product application. If signs of sensitivity occur, bathe your dog with mild soap or shampoo and rinse with large amounts of water. If signs of sensitivity occur and persist, contact a veterinarian immediately. If your dog has an unusual reaction to the initial application, consult a veterinarian before repeating application. Certain medications can interact with pesticides. Consult a veterinarian before using on medicated, debilitated, aged, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products. Consult a veterinarian for guidance on use against Sarcoptes mites. This product is not a substitute for a prescribed heartworm preventative.nCall 1-888-637-4251, for assistance. PHYSICAL OR CHEMICAL HAZARDS: Do not allow this product to come in contact with an oxidizing agent, as a hazardous chemical reaction may occur Harmful if swallowed. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid contact with skin. Wear (specify appropriate protective eyewear such as goggles, face shield, or safety glasses). Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash contaminated clothing before reuse.

Ingredients

Fipronil (9.8%)|(S)-Methoprene (8.8%)

Directions

Directions for Use Step 1. To REMOVE Applicator: 1. Use scissors to separate one blister; 2. Use scissors to cut along dotted line; 3. Peel down foil to remove the applicator. Step 2. OPEN Applicator. Hold upright with foil side toward you and snap applicator tip. Step 3. APPLY FRONTLINE Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the dog’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Do not allow your dog to ingest the product. Do not apply to dogs weighing less than 45 lbs. or younger than 8 weeks of age. Do not use more than one application per dog per month. Frequency Use monthly to control fleas and ticks. Do not reapply FRONTLINE Plus for 30 days.

Legal Disclaimer

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product.

Customer reviews

4.4 out of 5 stars
4.4 out of 5
27,304 global ratings

Customers say

Customers like the quality and ease of use of the pet supplies. For example, they mention it's a good solid product, it lasts 30+ days and it goes on easy. That said, opinions are mixed on performance, side effects, effectiveness, protection, and value.

AI-generated from the text of customer reviews

341 customers mention259 positive82 negative

Customers like the quality of the pet supplies. For example, they mention it's a good solid product that lasts 30+ days. Some say that the product appears intact, but the packaging had clearly already been opened. That said, most are happy with the product and find it easy to apply.

"...A good product for the price and it definitely last 30+ days." Read more

"...exceed 750PPM companies continue to ignore the guidline because it's cheap and effective, and sadly it's our dogs that pay the price...." Read more

"Good quality and great buy. Works as advertised." Read more

"...The tick was full, like a berry, and utterly disgusting, but the product worked. The tick was dead, as promised...." Read more

118 customers mention113 positive5 negative

Customers find the application of the pet supplies straightforward and easy. They also say it works well and is easy to dispense.

"The product is easy to use with easy to follow instructions! Works great for my girl and keeps her free of fleas and ticks!..." Read more

"...My dog has not bit or scratched himself and its very easy to apply on the back of his neck!" Read more

"Easy to apply" Read more

"Easy to use, always opt for these for our dogs" Read more

42 customers mention42 positive0 negative

Customers like the speed of the pet supplies. For example, they mention it works fast to get rid of flees, and is efficient. Some say the product is waterproof and goes on quick. The results were noticeable within 2 days. Overall, most are satisfied with the speed and effectiveness of the product.

"I like how fast acting this treatment is !" Read more

"Probably the best price you’ll find for Frontline anywhere. Works pretty fast and my dogs aren’t scratching anymore." Read more

"...It worked incredibly fast and effectively, providing relief for my furry friend almost immediately...." Read more

"Loves this product for dogs!! It works fast and is great if you are on a budget." Read more

1,187 customers mention532 positive655 negative

Customers are mixed about the performance of the pet supplies. Some mention that it works great, is effective, and has always worked within a few days. However, others say that it doesn't seem to work that well, maybe for a week, and stops working about 2 weeks before the next dose.

"...and because the product didn’t kill a tick before it bit my dog, I give it an average of 3 stars...." Read more

"The product is easy to use with easy to follow instructions! Works great for my girl and keeps her free of fleas and ticks!..." Read more

"I used it on my dog it doesn't seem to work that well maybe for a week she is a indoor dog and feel like I wasted my money I know I have used it..." Read more

"...I have used this for the last 3 months and it seems to work well...." Read more

668 customers mention367 positive301 negative

Customers are mixed about the effectiveness of the pet supplies. Some mention that it is very effective keeping the fleas and ticks off, and is the number one flea and tick prevention. However, others say that it didn't kill off all flea eggs within 48 hours, and a few days later their dogs still have flea.

"...Works great for my girl and keeps her free of fleas and ticks! Leaves her ready for adventure!" Read more

"...around 80 percent of the contents of Frontline Plus are not chemicals that fight pests, they are ethanol, glycol ether, and otherwise “inactive”..." Read more

"No fleas!!" Read more

"...I got this and put it on them. It did not kill off all fleas and eggs and such within 48 hours...." Read more

498 customers mention314 positive184 negative

Customers are mixed about the value of the pet supplies. Some mention it's very good for the price, while others say it'll be a waste of money.

"...A good product for the price and it definitely last 30+ days." Read more

"...I learned.Waste of time and money." Read more

"Good quality and great buy. Works as advertised." Read more

"Price and effectiveness." Read more

97 customers mention42 positive55 negative

Customers are mixed about the side effects of the pet supplies. Some mention that it caused no irritation, does not hurt their skin or fur, and does not cause their dog to itch. However, others say that it made their poor pup itch even more, develop numerous itchy bumps on their skin, and cause hair loss.

"...Repurchased the following month & now she is having allergic reaction. Itching & scratching. She has even lost a layer of hair...." Read more

"...Both of the chemicals, S-Methoprene and Fipronil are harmless to mammals...." Read more

"...reaction to the flea bites that she has itched herself raw and has dermatitis bumps...." Read more

"...after applying the product both are free of live fleas and look much more comfortable...." Read more

52 customers mention25 positive27 negative

Customers are mixed about the protection of the pet supplies. Some mention it's great protection, safe, and effective, while others say it'll harm your pet.

"...Permethrin is a lethal neurotoxin that flows through the dogs circulatory system and flushes into every major organ - including the brain where it..." Read more

"...They are happy, I am happy. And it didn't break the bank." Read more

"...This stuff has done NOTHING to prevent or kill any fleas. I end up having to use capstar to kill the fleas- and that only lasts 24hrs...." Read more

"Have used this product for years , provides good protection for my dog from" Read more

Works great
5 Stars
Works great
The product is easy to use with easy to follow instructions! Works great for my girl and keeps her free of fleas and ticks! Leaves her ready for adventure!
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Reviewed in the United States on March 17, 2024
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5.0 out of 5 stars Works great
Reviewed in the United States on March 17, 2024
The product is easy to use with easy to follow instructions! Works great for my girl and keeps her free of fleas and ticks! Leaves her ready for adventure!
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Reviewed in the United States on February 15, 2024
4 people found this helpful
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Reviewed in the United States on October 5, 2023
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Reviewed in the United States on March 16, 2024
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5.0 out of 5 stars Works great for our Australian Shepherd
Reviewed in the United States on March 16, 2024
Love how well this product works for our best friend! Will definitely continue to buy!
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Reviewed in the United States on March 7, 2018
307 people found this helpful
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Reviewed in the United States on March 24, 2024

Top reviews from other countries

Sen-Sen
4.0 out of 5 stars Good.
Reviewed in India on September 29, 2017