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FRONTLINE Brand Products: Flea and Tick Treatment OverviewBoehringer Ingelheim Animal Health

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FRONTLINE Plus for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) 8 Doses (Purple Box) ( Packaging May Vary )

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4.4 80,748 ratings

in Dog Flea Drops

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We don't know when or if this item will be back in stock.

Size: 8 Count

Color: Purple Box

Brand	Frontline
Item Form	Topical
Scent	Unscented
Age Range (Description)	All Life Stages
Item Weight	0.15 Pounds
Active Ingredients	fipronil and (S)-methoprene
Item Volume	12 Milliliters
Target Species	Dogs
Allergen Information	Gluten Free
Dog Breed Size	Large

About this item

Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease.
Break the flea life cycle with FRONTLINE Plus. Specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control.
Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days.
FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products.
Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations.
Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus.

Additional Details

Verified by Transparency

Each item has a unique code that we verify before shipping.

Customer ratings by feature

Easy to use

3.9

Scent

3.5

Easy to remove

3.3

Comfort

3.2

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Amazon Basics Flea and Tick Topical Treatment for Large Dogs (45-88 pounds), Unscented, 3 Count (Previously Solimo)

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From the brand

THE #1 NAME IN FLEA & TICK PROTECTION*

FRONTLINE Brand Products are effective topical solutions designed to help protect dogs and cats from fleas and ticks. FRONTLINE Plus and FRONTLINE Gold have formulas for dogs or cats. FRONTLINE Shield, with added mosquito repellency, is for dogs only.
FRONTLINE Plus for Dogs

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FRONTLINE Shield for Dogs

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FRONTLINE Plus for Cats

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FRONTLINE Gold for Dogs

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FRONTLINE Gold for Cats

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What is FRONTLINE?

FRONTLINE Brand Products are effective, easy-to-apply topical flea & tick preventives. FRONTLINE Plus and FRONTLINE Gold have formulas for dogs or cats. FRONTLINE Shield is for dogs only. All FRONTLINE Brand Products feature waterproof formulas that last a full 30 days.

Why should I protect my dog or cat from fleas & ticks?

Fleas & ticks are a year-round threat. FRONTLINE Brand Products help protect dogs or cats from these pests and monthly use can help prevent infestations.

From the manufacturer

Smiling man playing fetch outside with healthy dog. Frontline Plus awarded Newsweek most trusted

Frontline Plus has been trusted by pet owners for over 20 years and kills fleas and chewing lice

Answers to frequently asked questions about Frontline flea and tick prevention and treatment plans

How to Apply FRONTLINE Plus for Dogs


Read full instructions on packaging before use. Shown here: Size Large 45-88 lbs.	Use scissors to separate one blister. Hold applicator upright with foil side toward you and snap applicator tip off.	Part dog’s hair between shoulder blades until skin is visible.	Place applicator tip directly against exposed skin and apply entire contents directly to the skin. Do not apply on top of hair.


	FRONTLINE Plus for Small Dogs	FRONTLINE Plus for Medium Dogs	FRONTLINE Plus for Large Dogs	FRONTLINE Plus for X-Large Dogs	FRONTLINE Plus for Cats

Customer Reviews	80,748	21,075	80,748	13,801	43,618
Price	$65.45	$69.00	$69.00	$67.14	$69.00
Recommended pet size	5 to 22 pounds	23 to 44 pounds	45 to 88 pounds	89 to 132 pounds	Cats and kittens over 1.5 pounds
Kills adult fleas, flea eggs, and flea larvae	✓	✓	✓	✓	✓
Kills ticks and chewing lice	✓	✓	✓	✓	✓
Minimum age of pet for use	Dogs and puppies 8 weeks and older	Dogs and puppies 8 weeks and older	Dogs and puppies 8 weeks and older	Dogs and puppies 8 weeks and older	Cats and kittens 8 weeks and older
Available sizes	3, 6 and 8-Dose	3, 6 and 8-Dose	3, 6 and 8-Dose	3, 6 and 8-Dose	3, 6 and 8-Dose
	Do not use on cats	Do not use on cats	Do not use on cats	Do not use on cats	For use on cats only

Product information

Item Weight

2.4 ounces

Manufacturer

Boehringer Ingelheim Animal Health

ASIN

B07NGNFCCJ

Item model number

72219

Customer Reviews

4.4 80,748 ratings

4.4 out of 5 stars

Date First Available

February 7, 2019

Item Package Dimensions L x W x H

6 x 4.5 x 1 inches

Item Dimensions LxWxH

1 x 5.75 x 4.5 inches

Item Weight

0.15 Pounds

Brand Name

Frontline

Target Audience Keyword

house-cats, dogs

Directions

1. Part your dog's hair at the shoulder blades. 2. Apply content of applicator to the skin. 3. Repeat every 30 days for continuous protection.

Country of Origin

France

Warranty Description

If you are not satisfied with Frontline Plus for any reason, please contact the Boehringer-Ingelheim Animal Health Customer Care Team at: 1-800-660-1842.

Model Name

Frontline Plus

Color

Purple Box

Size

8 Count

Age Range Description

All Life Stages

Number of Items

Manufacturer

Boehringer Ingelheim Animal Health

Style

Large Dog (45-88 lbs.)

Breed Recommendation

Large

Included Components

Applicator

Specific Uses for Product

Active, Outdoor, Parasites, Indoor

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Product details

Product Dimensions ‏ : ‎ 1 x 5.75 x 4.5 inches; 2.4 ounces
Item model number ‏ : ‎ 72219
Date First Available ‏ : ‎ February 7, 2019
Manufacturer ‏ : ‎ Boehringer Ingelheim Animal Health
ASIN ‏ : ‎ B07NGNFCCJ

Best Sellers Rank: #15 in Pet Supplies (See Top 100 in Pet Supplies)
- #1 in Dog Flea Drops

Customer Reviews:
4.4 80,748 ratings

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Product Description

Keep your dog protected with the #1 name in flea & tick protection*, FRONTLINE®. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years**— FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: *Data on file at Boehringer Ingelheim. **Data showing 20 years of trust in killing fleas and ticks is on file at Boehringer Ingelheim.

Top Brand: Frontline

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Important information

Safety Information

KEEP OUT OF REACH OF CHILDREN. WARNING: PRECAUTIONARY STATEMENTS - HAZARDS TO HUMANS: WARNING. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid Contact with skin. Harmful if swallowed. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash clothing that may have come in contact with the product before reuse. HAZARDS TO DOMESTIC ANIMALS: For external use on dogs ONLY. Do not use on animals other than dogs. Do not use on dogs under 9 weeks of age or weighing less than 5 lbs. Individual sensitivities may occur after using ANY pesticide product. Dogs may experience some temporary irritation at the site of product application. If signs of sensitivity occur, bathe your dog with mild soap or shampoo and rinse with large amounts of water. If signs of sensitivity occur and persist, contact a veterinarian immediately. If your dog has an unusual reaction to the initial application, consult a veterinarian before repeating application. Certain medications can interact with pesticides. Consult a veterinarian before using on medicated, debilitated, aged, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products. Consult a veterinarian for guidance on use against Sarcoptes mites. This product is not a substitute for a prescribed heartworm preventative.nCall 1-888-637-4251, for assistance. PHYSICAL OR CHEMICAL HAZARDS: Do not allow this product to come in contact with an oxidizing agent, as a hazardous chemical reaction may occur Harmful if swallowed. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid contact with skin. Wear (specify appropriate protective eyewear such as goggles, face shield, or safety glasses). Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash contaminated clothing before reuse.

Directions

1. Part your dog's hair at the shoulder blades. 2. Apply content of applicator to the skin. 3. Repeat every 30 days for continuous protection.

Compare with similar items

	This Item FRONTLINE Plus for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) 8 Doses (Purple Box) ( Packaging May Vary )	Recommendations Frontline Gold Flea & Tick Treatment for Large Dogs Up to 45 to 88 lbs., Pack of 6	dummy FRONTLINE Shield Flea & Tick Treatment for Large Dogs 41-80 lbs., Count of 6	dummy FRONTLINE Gold Flea & Tick Treatment for Medium Dogs Up to 23 to 44 lbs., Pack of 6	dummy FRONTLINE Shield Flea & Tick Treatment for X-Large Dogs 81-120 lbs., Count of 3	dummy Frontline Gold Flea & Tick Treatment for X-Large Dogs Up to 89 to 132 lbs., Pack of 3
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Price	Currently unavailable.	-14% $81.56 Typical: $94.99	$82.98	$94.99	-15% $39.93 List: $46.99	$54.99
Delivery	—	Get it as soon as Saturday, May 11	Get it as soon as Saturday, May 11	Get it May 10 - 14	Get it as soon as Saturday, May 11	Get it as soon as Saturday, May 11
Customer Ratings	4.480,748	4.5567	4.31,393	4.3149	4.4387	4.5117
Easy to use	3.9	4.4	4.0	3.9	4.2	4.7
Scent	3.5	4.4	4.0	3.5	3.3	3.0
Value for money	3.0	3.8	3.2	2.5	3.0	3.8
Flavor	2.7	2.4	2.9	—	3.0	—
Sold By	—	Amazon.com	Amazon.com	Petco	Amazon.com	Amazon.com
target audience	Dogs	Adult	Dog	Adult	Dog	Adult
age range	All Life Stages	All Life Stages	All Life Stages	All Life Stages	All Life Stages	All Life Stages
scent	Unscented	No Scent	Topical	No Scent	Topical	No Scent
form	Topical	Stick	Stick	Stick	Stick	Stick
volume	12 milliliters	16.08 milliliters	24 milliliters	8.04 milliliters	18 milliliters	12.06 milliliters
active ingredients	fipronil and (S)-methoprene	Fipronil, (S)-methoprene, Pyriproxyfen	Fipronil, Permethrin, Pyriproxyfen	Fipronil, (S)-methoprene, Pyriproxyfen	Fipronil, Permethrin, Pyriproxyfen	Fipronil, (S)-methoprene, Pyriproxyfen
weight	0.15 pounds	0.1 pounds	0.81 ounces	—	—	—

Customer reviews

4.4 out of 5

80,748 global ratings

How customer reviews and ratings work

Customers say

Customers like the protection and quality of the pet pest control. For example, they mention it provides good protection for their dogs from fleas, ticks, lice, larvae, eggs, and mosquitoes. They also like the ease of use. That said, opinions are mixed on safety, value, flea control, comfort, and performance.

AI-generated from the text of customer reviews

1,134 customers mention968 positive166 negative

Customers like the quality of the pet pest control. They say it's a high-quality product that delivers real results and gives them peace of mind. Some say it builds complimentary characteristics you wouldn't otherwise have. They are happy to know it'd be safe to use on their dog and that it'll never have a bad reaction or side effect.

"Good product" Read more

"...Bathing the second dog tomorrow! Great results…great product!" Read more

"...Their coats are shiny, they're not scratching every two seconds, and they've even started to learn new tricks...." Read more

"trustable" Read more

490 customers mention464 positive26 negative

Customers find the pet pest control product easy to use. They mention that it's simple, convenient, and not too much of a pain to apply. They also say the application process is smooth and the impact of applying the product is almost immediate.

"Super easy to use and apply. No smell, no unusual behavior from our dog afterwards...." Read more

"Easy to use and includes stickers to add to your calendar so easy to remember when the next dose is due." Read more

"...I personally like it because no flea collars. Not too much of a pain once a month." Read more

"...This applicator was easy, simple, and in one spot." Read more

244 customers mention199 positive45 negative

Customers like the protection provided by the pet pest control product. They say it's a great product to protect dogs from fleas, ticks, lice, larva, eggs, and mosquitoes. They mention that it'd be safe to use on herding breeds and is harmless to mammals.

"...size of your dog toxicity is far easier to avoid and the product much safer for your dog...." Read more

"Product really works, easy to apply and not invasive to my dog." Read more

"Works quite well to protect are little wonder dog Daisy from fleas and ticks." Read more

"No flees here. One of the best products we have gotten for our dogs ." Read more

4,074 customers mention1,813 positive2,261 negative

Customers are mixed about the performance of the pet pest control product. Some mention it works very good on their dogs to repel fleas and ticks, while others say it doesn't seem to work that well. Some say the formula has been weakened or watered down, and it stops working about 2 weeks before the next dose.

"...Keep in mind, this does not work immediately, and the instructions even state this fact. It takes time to work...." Read more

"I have been using this brand of product for years and it works amazing, I give my dog a bath and dry her with a towel and then just let her air dry..." Read more

"...It's been several weeks now and I see no improvement. It just did not work at all. The fleas have become immune to it. Or I just got a bad batch...." Read more

"...companies continue to ignore the guidline because it's cheap and effective, and sadly it's our dogs that pay the price...." Read more

2,087 customers mention1,133 positive954 negative

Customers are mixed about the flea control. Some mention that it keeps fleas and ticks off well, while others say that it doesn't really go away and that their pets are still infested with flea activity.

"...manchester terrier is completely healthy and fine after usage, and pest free." Read more

"...The tick was full, like a berry, and utterly disgusting, but the product worked. The tick was dead, as promised...." Read more

"Would not go without using, prevents fleas, ticks and so on." Read more

"...I got this and put it on them. It did not kill off all fleas and eggs and such within 48 hours...." Read more

1,872 customers mention1,262 positive610 negative

Customers are mixed about the value of the pet pest control product. Some mention it's very good for the price, saves money, and is worth the cash. However, others say it'd be a waste of money.

"...exceed 750PPM companies continue to ignore the guidline because it's cheap and effective, and sadly it's our dogs that pay the price...." Read more

"...A good product for the price and it definitely last 30+ days." Read more

"Works as ordered. A little expensive but works" Read more

"Great product and price" Read more

225 customers mention96 positive129 negative

Customers are mixed about the comfort of the pet pest control. Some mention that the drops work well without making their pet itchy, and does not hurt their skin or fur. However, others say that the itching comes back in few days.

"...Repurchased the following month & now she is having allergic reaction. Itching & scratching. She has even lost a layer of hair...." Read more

"...They have been so peaceful and restful since we applied this. I have not seen them scratch one time...." Read more

"...developed a horrible smell as it reacted to their skin, and they began itching and scratching furiously at the application site...." Read more

"...after applying the product both are free of live fleas and look much more comfortable...." Read more

201 customers mention115 positive86 negative

Customers are mixed about the safety of the pet pest control. Some mention it's great for the dogs, easy to use, and keeps the tics off their dogs. However, others say that their dogs actually get ill when it'd applied, and has a short-term effect on the dog. They also say that it did nothing to help their dogs with fleas, and killed their unborn puppies in 2018.

"Easy to use and great for the dogs." Read more

"...The next day there was no change & the dog seemed to have even more...." Read more

"...Frontline is the only product I found to keep the tics off my dogs. Plus I like the way the containers open and it’s easy to apply." Read more

"...is essentially a poison to ticks and fleas, it also has a short term effect on the dog (usually mild diarrhea)...." Read more

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Top reviews from the United States

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Works, safe, but not instant results

Reviewed in the United States on April 12, 2024

Size: 3 countColor: Orange BoxVerified Purchase

Super easy to use and apply. No smell, no unusual behavior from our dog afterwards. Keep in mind, this does not work immediately, and the instructions even state this fact. It takes time to work.

By month three, after the third application our flea problem was completely gone.

Before we started using this product the fleas has gotten so bad that they were in multiple areas of the house the dog had been. Using only this product and vacuuming and cleaning regularly completely eradicated the nuisance. Most importantly, our manchester terrier is completely healthy and fine after usage, and pest free.

5 people found this helpful

Helpful

Susan J. Coler

Works well for keep Ticks away.

Reviewed in the United States on April 30, 2024

Size: 3 CountColor: Purple BoxVerified Purchase

Easy to use and includes stickers to add to your calendar so easy to remember when the next dose is due.

One person found this helpful

Helpful

loren tapp

love this stuff

Reviewed in the United States on April 17, 2024

Size: 3 CountColor: Purple BoxVerified Purchase

I have been using this brand of product for years and it works amazing, I give my dog a bath and dry her with a towel and then just let her air dry then i put Frontline Plus on my dog and it lasts a while i only apply once a month or once ever month in a half,

3 people found this helpful

Helpful

Peter Suslock

Your Safest Bet For A Product You Wish You Didn't Need.

Reviewed in the United States on August 18, 2012

Size: 6 CountColor: Purple BoxVerified Purchase

Allow me to caveat this review by saying out of 700 plus reviews this is the most difficult to write as I despise having to use pesticides on our dogs. That said, we live in Tick and Flea central, surrounded by deep woods and our bulldogs are in every sense of the word family and we do whatever we must to protect them. That said if you're reading these reviews your dog or dogs are your heart too and using these products is a difficult choice to make, but it's one we have to make.

On that note, it's my hope the following information has some value for you.

Frontline was first put into clinical trials in 1985 shortly after the discovery of it's active ingredient Fipronil. To it's credit Frontline has maintained the safest albeit not the most effective treatment for fleas and ticks. However, the more effective products pose a significantly greater risk to your dog.
It's a slippery slope, but in evaluating what's best for your dog by providing the highest level protection with the lowest risk Frontline and FrontLine Plus are in my opinion your best bet.

Most tick and flea products contain Permethrin which may also be listed as Lyclear or Nix as the active ingredient. Permethrin is a lethal neurotoxin that flows through the dogs circulatory system and flushes into every major organ - including the brain where it can do dire damage. Thousands of dogs die every year from Permethrin. Although the FDA has mandated a minimal use not to exceed 750PPM companies continue to ignore the guidline because it's cheap and effective, and sadly it's our dogs that pay the price.

What makes Permethrin so dangerous is that it can't distinguish between insects and mammals which of course includes human beings. It's been known to be lethal to cats since the 1970's. In fact it's so deadly to cats that even a slight transfer from dog to cat can result in seizures, brain damage and death. Permethrin is volatile as well - meaning it's airborne properties pose a threat to all who breath it in - humans included.

Frontline on the other hand uses Fipronil. Fipronil is an insecticide.

Like any chemical of this nature it can be lethal at too high of a dose. However studies including those from the Department of Environmental Conservation have determined time and time again that as long as the amount of Fipronil is at the correct dose for the weight and size of your dog toxicity is far easier to avoid and the product much safer for your dog. Unlike Premethrin, Fipronil is absorbed into the hair follicles and oil glands only. It is not absorbed into the dogs system nor is it volatile so you and your beloved pets and children can breath easy. The second active ingredient in FrontLine Plus is Methoprene which is a long existing and time proven IGR (insect growth regulator) it's distributed exactly like Fipronil but only acts on flea and tick eggs and Larvae - this is important because it kills these vermin at the start of a new life cycle. What is more, the diseases that ticks carry now are infinitely more serious than the dreaded Lime disease - which for decades was the only concern.

Competitors to Frontline (and some Vets selling other products) claim that fleas and ticks have become resistant to Frontline - However these pests have become resistant to some degree to all pesticides and no independent research exists to confirm this claim. I can assure you I've researched this in the greatest depth.

The bottom line is this - all of these products pose a risk.

The wise choice is to minimize that risk in your effort to protect your best friend from the diseases these vermin carry. Again, these diseases can be infinitely more lethal than the ingredients of the protection. To that end your safest and most effective choice is Frontline or Frontline Plus.

In the event your pet has a bad reaction to Frontline products these are the symptoms you would see:

* Restlessness

* Itching

* Vomiting

* Difficulty Breathing

* Lethargy

Should these symptoms occur, of course take your pet to your Veterinarian or emergency clinic immediately. It should be a comfort to know that unlike the toxic ingredients in most other flea and tick control products severe reactions to both Fipronil and Methoprene are rare.

1,691 people found this helpful

Helpful

shelby Jablonski

Great product

Reviewed in the United States on April 18, 2024

Size: 3 countColor: Orange BoxVerified Purchase

Would not go without using, prevents fleas, ticks and so on.

One person found this helpful

Helpful

Christine Backus

Flea protection for dogs

Reviewed in the United States on May 1, 2024

Size: 3 countColor: Orange BoxVerified Purchase

Works great. My dog is unable to take chewables because they make him sick, so this is a better alternative for him.

Helpful

Chris

Protects dog-Kills bugs-Bit tedious to apply

Reviewed in the United States on April 3, 2024

Size: 3 CountColor: Purple BoxVerified Purchase

Had to straddle my dog by pinching knees while standing. For dogs with thicker coat it maybe hard to get to the skin so it can be absorbed. I personally like it because no flea collars. Not too much of a pain once a month.

2 people found this helpful

Helpful

Ash Carlton

No more fleas.

Reviewed in the United States on April 15, 2024

Size: 3 CountColor: Purple BoxVerified Purchase

This stuff works great. I use it on both of my dogs.

2 people found this helpful

Helpful

Top reviews from other countries

Douglas fernandes

Four Stars

Reviewed in India on September 5, 2017

Size: 6 CountColor: Purple BoxVerified Purchase

It was very helpful I managed to get control of the continue scratching on her back

Sen-Sen

Good.

Reviewed in India on September 29, 2017

Size: 3 CountColor: Purple BoxVerified Purchase

It works

See more reviews

FRONTLINE Plus for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) 8 Doses (Purple Box) ( Packaging May Vary )

About this item

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