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Advantage II XL Dog Vet-Recommended Flea Treatment & Prevention | Dogs Over 55 lbs. | 6-Month Supply

4.6 4.6 out of 5 stars 3,276 ratings

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About this item

  • Vet recommended flea treatment and prevention for dogs at weighing over 55 lbs., at least 7 weeks of age
  • Kills adult fleas, flea larvae and flea eggs for total flea prevention and treatment
  • Same-day effectiveness, kills fleas within 12 hours of application and keeps working for 30 days
  • Easy-to-apply topical treatment, no prescription needed
  • Fragrance-free formula, waterproof after 24 hours

Customer ratings by feature

Easy to use
4.5 4.5
Comfort
4.0 4.0
Value for money
3.9 3.9

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Advantage II XL Dog Vet-Recommended Flea Treatment & Prevention | Dogs Over 55 lbs. | 6-Month Supply
Advantage II XL Dog Vet-Recommended Flea Treatment & Prevention | Dogs Over 55 lbs. | 6-Month Supply
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Price$66.98$55.96-10% $17.99
List:$19.99
-12% $79.98
List:$91.18
$79.98-14% $38.60
List:$44.99
Delivery
Get it as soon as Sunday, Mar 31
Get it as soon as Sunday, Mar 31
Get it as soon as Sunday, Mar 31
Get it as soon as Sunday, Mar 31
Get it as soon as Sunday, Mar 31
Customer Ratings
Easy to use
4.5
4.6
3.2
4.2
4.2
4.0
Value for money
3.9
3.5
1.7
3.5
3.4
3.0
Comfort
4.0
2.5
3.5
3.6
3.1
Scent
3.4
3.7
3.4
Flavor
2.1
2.8
2.4
Sold By
Amazon.com
Pets Go Here - Pet Store
PETIQ
Amazon.com
Amazon.com
Amazon.com
target audience
Adult
Adult
Dog, Dog, Dog, Dog, Dog
Dog
Dog
Dog
age range
7 weeks and older
Kitten
All Life Stages
7 weeks and older
7 weeks and older
All Life Stages
scent
Unscented
Unscented
Unscented
Topical
form
Topical
Drops
Drops
Topical
Topical
Oil
volume
24 milliliters
2 fluid ounces
24 milliliters
1 quarts
16.08 milliliters
active ingredients
Imidacloprid, Pyriproxyfen
Fipronil, Cyphenothrin, (S)-methoprene
Imidacloprid, Permethrin, Pyriproxyfen
Imidacloprid, Permethrin, Pyriproxyfen
Fipronil, Methoprene

From the manufacturer

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Kills and Protects

Kills adult fleas, flea larvae, and flea eggs to break the flea life cycle, and prevents flea and lice infestations for 30 days

Same-Day Effectiveness

Starts to kill fleas and lice on dogs within 12 hours of application and continues to prevent reinfestations.

Vet-Recommended

A leading brand in dog flea treatment and prevention, recommended for dogs over 55 lbs.

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About Advantage II

  • Easy-to-apply topical solution – no hard-to-swallow pills
  • 30-day protection
  • Fragrance-free, waterproof formula*

*24 hours after application

Easy Application - Step 1

Holding the tube upright and pointed away from you and your pet, remove the cap from the applicator tube. Turn the cap around, place it back on the tube and twist to break the seal.

Easy Application - Step 2

Be sure to use the entire tube of Advantage II when applying it to your dog. Part the hair on your dog’s back between the shoulder blades until the skin is visible. Squeeze the tube to expel the entire contents directly on the skin in 1-4 spots, depending on your dog’s weight.See the product label for specific application instructions by weight.

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Advantage II Extra Large Dog Seresto Large Dog K9 Advantix II Extra Large Dog advantus Advantage Treatment Shampoo
Customer Reviews
4.6 out of 5 stars
3,276
4.5 out of 5 stars
99,427
4.5 out of 5 stars
42,529
4.2 out of 5 stars
12,138
4.4 out of 5 stars
1,666
Form Topical Drops Collar Topical Drops Flea Soft Chew Tick and Flea Shampoo
Treatment Treatment + Prevention Treatment + Prevention Treatment + Prevention Treatment Treatment
Application Frequency Monthly Every 8 Months Monthly Do Not Exceed One Soft Chew in a 24-hour Period See Product Label
Kills Fleas?
Kills Ticks?
Starts to Kill Fleas Within 12 hours 24 hours 12 hours 1 hour On Contact

Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 1.38 x 4.38 x 6.63 inches; 2.56 ounces
  • Item model number ‏ : ‎ 86336669
  • Department ‏ : ‎ Flea & Tick
  • Date First Available ‏ : ‎ March 5, 2011
  • Manufacturer ‏ : ‎ Elanco US Inc
  • ASIN ‏ : ‎ B004QRJJF0
  • Customer Reviews:
    4.6 4.6 out of 5 stars 3,276 ratings

Product Description

Advantage II Extra Large Dog is the vet-recommended prevention and treatment of flea and lice infestations in dogs. Advantage II Extra Large Dog flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your dog or puppy. In fact, within 12 hours of application, Advantage II Extra Large Dog topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your dog to die.

This 30-day treatment effectively breaks the flea life cycle, controlling existing flea and lice infestations and preventing further infestations all month long. Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Extra Large Dog is important to protect your dog against fleas that may cause transmission of tapeworms in dogs, Flea Allergy Dermatitis and flea bite anemia.

That’s why Advantage II topical, spot-on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.

Advantage II Extra Large Dog flea and lice protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh over 55 lbs. to use Advantage II Extra Large Dog.

For the ultimate convenience in care, Advantage II Extra Large Dog is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Once Advantage II Extra Large Dog is applied, your dog is ready to get right back to exploring his favorite places – from the backyard to the dog park.

Advantage II Extra Large Dog is a trademark of Elanco or its affiliates.

Product guides and documents

Looking for specific info?

Important information

Ingredients

Imidacloprid…………….9.10% Pyriproxyfen……………0.46% Other Ingredients………90.44% Total…………………….100.00%

Directions

Application Instructions: 1. Use only on dogs. 2. Hold applicator tube in an upright position. Pull cap off tube. 3. Turn the cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. 4. Apply the entire contents of the tube evenly to three or four spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. 5. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. 6. Do not apply an excessive amount of solution at any one spot that could cause the solution to run off the side of the dog. 7. Do not get this product in your dog’s eyes or allow them to ingest.

Customer reviews

4.6 out of 5 stars
4.6 out of 5
3,276 global ratings

Customers say

Customers like the quality, ease of use, and value of the pet supplies. They mention that it works well, is easy to apply, and is cost-effective. Some appreciate the visual instructions.

AI-generated from the text of customer reviews

415 customers mention303 positive112 negative

Customers like the quality of the pet supplies. They say it works well for fleas, and is easy to apply. Some say they're pleased with the results and will continue to use the product. Overall, most are happy with their purchase and recommend it to others.

"I like that it doesn't smell terrible. And not even bad for very long. It's nice and oily so I know it's coating their fur well. Price is economical...." Read more

"...This is the only over-the-counter product that works for my pets and stops the flea cycle...." Read more

"Works great on cats too with no bad side effects." Read more

"...for my cats since it was the same, but all it does now is make the fleas really angry...." Read more

130 customers mention110 positive20 negative

Customers like the value of the pet supplies. They mention it's great value for the money and a huge money saver.

"...It's nice and oily so I know it's coating their fur well. Price is economical. One box did all mine for more than a month" Read more

"...This is more cost effective & I have found that I can control the fleas by using a smaller dosage for my 30lb dog with allergies...." Read more

"Good price, quick shipping" Read more

"...animals buying this in quantity is actually saving money and way better price than veterinary has" Read more

21 customers mention21 positive0 negative

Customers find the pet supplies easy to use. They mention that the application is simple, and the product works fast. Customers also appreciate the visual instructions, which make the application process less frustrating.

"Works as it should, kills fleas. easy to apply. Best value here on Amazon." Read more

"Well instructed, formula works fast...." Read more

"...This is a good product, is easy to apply and so far has kept my Dobie free of fleas...." Read more

"...Sometimes not.The application is easy.My only complaint is the price, especially since I have two extra-large dogs." Read more

20 customers mention16 positive4 negative

Customers like the side effects of the pet supplies. They mention that it doesn't harm the animal, it controls fleas well, and is safe for cats. Some say that it does a great job protecting the dogs from flea.

"Works great on cats too with no bad side effects." Read more

"This is by far the best product for our dogs." Read more

"...Plus the cats don't get spooked out by the hissing and spitting of the empty bottle as the last of the dose comes out, the syringe is silent...." Read more

"This made my dog go crazy. He literally would not stop pacing. I've never seen him act like that before...." Read more

Really works!
5 Stars
Really works!
I have tried many different versions of flea medications, both prescribed and available over-the-counter and this is the best one I have ever come across. In Florida we have some really vicious fleas that seem to be immune to some of the other products that are on the market. This is the only over-the-counter product that works for my pets and stops the flea cycle. The first time I ever used Advantage II, was on my cats. I applied it on the back of their necks and left them sleeping on my bed. When I came back, I couldn't believe my eyes. There were dead and dying fleas all over my bed and it was completely disgusting. There were also these small light orange things that may have been flea eggs and small white worms. I have never seen that type of thing happen with any other flea product before and I've tried most of them. I now apply the product and then lay down old towels and put the pets in a room by themselves. After a few hours I come in,  throw the towels away and clean the room completely from top to bottom and vacuum thoroughly. We have not had a flea infestation thanks to this stuff. I purchase the extra large dose for my 4 dogs and give each of my pets the amount recommended by my Vet from the one vial. One extra large dose is enough flea medication for all four of my dogs. I highly recommend giving Advantage II a try. It really does work to kill all the life stages of fleas and will break the flea cycle.
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Top reviews from the United States

Reviewed in the United States on March 5, 2024
Reviewed in the United States on September 17, 2016
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5.0 out of 5 stars Really works!
Reviewed in the United States on September 17, 2016
I have tried many different versions of flea medications, both prescribed and available over-the-counter and this is the best one I have ever come across. In Florida we have some really vicious fleas that seem to be immune to some of the other products that are on the market. This is the only over-the-counter product that works for my pets and stops the flea cycle. 

The first time I ever used Advantage II, was on my cats. I applied it on the back of their necks and left them sleeping on my bed. When I came back, I couldn't believe my eyes. There were dead and dying fleas all over my bed and it was completely disgusting. There were also these small light orange things that may have been flea eggs and small white worms. I have never seen that type of thing happen with any other flea product before and I've tried most of them. 

I now apply the product and then lay down old towels and put the pets in a room by themselves. After a few hours I come in,  throw the towels away and clean the room completely from top to bottom and vacuum thoroughly. We have not had a flea infestation thanks to this stuff. I purchase the extra large dose for my 4 dogs and give each of my pets the amount recommended by my Vet from the one vial. One extra large dose is enough flea medication for all four of my dogs. 

I highly recommend giving Advantage II a try. It really does work to kill all the life stages of fleas and will break the flea cycle.
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