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Advantage II XL Dog Vet-Recommended Flea Treatment & Prevention | Dogs Over 55 lbs. | 4-Month Supply

4.5 4.5 out of 5 stars 2,971 ratings
Amazon's Choice highlights highly rated, well-priced products available to ship immediately.
Amazon's Choice in Dog Flea Drops by Advantage

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About this item

  • Vet recommended flea treatment and prevention for dogs at weighing over 55 lbs., at least 7 weeks of age
  • Kills adult fleas, flea larvae and flea eggs for total flea prevention and treatment
  • Same-day effectiveness, kills fleas within 12 hours of application and keeps working for 30 days
  • Easy-to-apply topical treatment, no prescription needed
  • Fragrance-free formula, waterproof after 24 hours

Customer ratings by feature

Easy to use
4.3 4.3
Value for money
3.6 3.6
Comfort
3.4 3.4

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From the manufacturer

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Dog lovers choose Advantage II Extra Large Dog

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Kills and Protects

Kills adult fleas, flea larvae and flea eggs to break the flea life cycle and prevents flea and lice infestations for 30 days.

Same-Day Effectiveness

Starts to kill fleas and lice on dogs within 12 hours of application and continues to prevent reinfestations.

Vet-Recommended

A leading brand in dog flea treatment and prevention, recommended for dogs over 55 lbs.

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About Advantage II

  • Easy-to-apply topical solution – no hard-to-swallow pills
  • 30-day protection
  • Fragrance-free, waterproof formula*

*24 hours after application

Easy Application - Step 1

Holding the tube upright and pointed away from you and your pet, remove the cap from the applicator tube. Turn the cap around, place it back on the tube and twist to break the seal.

Easy Application - Step 2

Be sure to use the entire tube of Advantage II when applying it to your dog. Part the hair on your dog’s back between the shoulder blades until the skin is visible. Squeeze the tube to expel the entire contents directly on the skin in 1-4 spots, depending on your dog’s weight.See the product label for specific application instructions by weight.

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Advantage II Extra Large Dog Seresto Large Dog K9 Advantix II Extra Large Dog advantus Advantage Treatment Shampoo
Customer Reviews
4.5 out of 5 stars
2,971
4.5 out of 5 stars
99,461
4.5 out of 5 stars
42,528
4.2 out of 5 stars
12,142
4.4 out of 5 stars
1,666
Form Topical Drops Collar Topical Drops Flea Soft Chew Tick and Flea Shampoo
Treatment Treatment + Prevention Treatment + Prevention Treatment + Prevention Treatment Treatment
Application Frequency Monthly Every 8 Months Monthly Do Not Exceed One Soft Chew in a 24-hour Period See Product Label
Kills Fleas?
Kills Ticks?
Starts to Kill Fleas Within 12 hours 24 hours 12 hours 1 hour On Contact

Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 6.5 x 1 x 4.25 inches; 1.6 ounces
  • Manufacturer recommended age ‏ : ‎ 1 month and up
  • Item model number ‏ : ‎ 81520305
  • Department ‏ : ‎ Unisex-Adult
  • Date First Available ‏ : ‎ July 15, 2004
  • Manufacturer ‏ : ‎ Elanco US Inc
  • ASIN ‏ : ‎ B004QBL9IQ
  • Customer Reviews:
    4.5 4.5 out of 5 stars 2,971 ratings

Looking for specific info?

Product Description

Product Description

Advantage II Extra Large Dog is the vet-recommended prevention and treatment of flea and lice infestations in dogs. Advantage II Extra Large Dog flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your dog or puppy. In fact, within 12 hours of application, Advantage II Extra Large Dog topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your dog to die.

This 30-day treatment effectively breaks the flea life cycle, controlling existing flea and lice infestations and preventing further infestations all month long. Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Extra Large Dog is important to protect your dog against fleas that may cause transmission of tapeworms in dogs, Flea Allergy Dermatitis and flea bite anemia.

That’s why Advantage II topical, spot-on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.

Advantage II Extra Large Dog flea and lice protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh over 55 lbs. to use Advantage II Extra Large Dog.

For the ultimate convenience in care, Advantage II Extra Large Dog is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Once Advantage II Extra Large Dog is applied, your dog is ready to get right back to exploring his favorite places – from the backyard to the dog park.

Advantage II Extra Large Dog is a trademark of Elanco or its affiliates.

Brand Story

By Advantage

Important information

Ingredients

Imidacloprid…………….9.10% Pyriproxyfen……………0.46% Other Ingredients………90.44% Total…………………….100.00%

Directions

Application Instructions: 1. Use only on dogs. 2. Hold applicator tube in an upright position. Pull cap off tube. 3. Turn the cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. 4. Apply the entire contents of the tube evenly to three or four spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. 5. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. 6. Do not apply an excessive amount of solution at any one spot that could cause the solution to run off the side of the dog. 7. Do not get this product in your dog’s eyes or allow them to ingest.

Compare with similar items

This Item
Advantage II XL Dog Vet-Recommended Flea Treatment & Prevention | Dogs Over 55 lbs. | 4-Month Supply
Advantage II XL Dog Vet-Recommended Flea Treatment & Prevention | Dogs Over 55 lbs. | 4-Month Supply
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Advantage XD Small Cat Flea Prevention & Treatment For Cats 1.8-9lbs. | 1-Topical Dose, 2-Months of Protection Per Dose
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Advantage II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 4-Month Supply
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Price$47.96$55.96$34.98-6% $53.98
List:$57.48
$79.98-11% $50.98
List:$57.58
Delivery
Customer Ratings
Easy to use
4.3
4.6
3.9
4.2
4.2
4.1
Value for money
3.6
3.5
3.4
3.5
3.4
3.4
Scent
3.4
3.6
3.7
3.6
Comfort
3.4
3.5
3.6
Sold By
Better Price For You LLC
Pets Go Here - Pet Store
Amazon.com
Reviluxe
Amazon.com
Amazon.com
target audience
Dog, Dog, Dog Flea And Tick, Dog Flea And Tick Topicals, PetSupplies
Adult
Dog
Dog
Dog
age range
7 weeks and older
Kitten
8 weeks and older
7 weeks and older
7 weeks and older
7 weeks and older
scent
Unscented
Unscented
Unscented
Unscented
Unscented
form
Topical
Drops
Topical
Topical
Topical
Topical
volume
16 milliliters
2 fluid ounces
1 milliliters
16 milliliters
1 quarts
10 milliliters
active ingredients
Imidacloprid, Pyriproxyfen
Spinetoram
Imidacloprid, Permethrin, Pyriproxyfen
Imidacloprid, Permethrin, Pyriproxyfen
Imidacloprid, Pyriproxyfen
weight
0.1 pounds
0.05 pounds
0.71 ounces
0.13 pounds
0.15 pounds
0.04 pounds

Customer reviews

4.5 out of 5 stars
4.5 out of 5
2,971 global ratings

Customers say

Customers like the quality, value, ability to fleas and safety of the pet supplies. For example, they mention that it works well, is cost effective and worth the money. They appreciate the ease of use and versatility.

AI-generated from the text of customer reviews

416 customers mention294 positive122 negative

Customers like the quality of the pet supplies. They say it works well, has amazing results, and is potent. Some say it's the best on the market.

"My dog had fleas…now she doesn’t! Works great!" Read more

"...The chemical that is in this product started out working very well. Over the years it seems to be losing its effectiveness earlier each month...." Read more

"...regularly gets into water (pool, beach, sprinklers), the Advantage wears off much quicker, despite claiming to be waterproof...." Read more

"...I didn't care for the smell, but man it's potent. My dog did not habe a seizure..." Read more

151 customers mention116 positive35 negative

Customers like the ability of the pet supplies to keep fleas away. They mention that it not only kills the flea, but it also kills their eggs. Some say that after 3 days, almost all the flees are gone. Customers also say that it is the best topical flea control and that they have never seen flea on any of their cats.

"...Other than that, Advantage II is, in my opinion, the best topical flea control." Read more

"...but it is the only brand that I have found to ever kill and get rid of fleas completely, I've tried so many too!..." Read more

"...This stuff works great at killing fleas and preventing re infestation. I definitely recommend this product!..." Read more

"...I'm combing morning, noon and night it seems, and nothing. No dead fleas, no dying fleas, no die off in the carpets, and that despite the use of..." Read more

143 customers mention105 positive38 negative

Customers like the value of the pet supplies. They mention that it's much more cost effective than the small dog or chewable, and worth the money.

"...I am brand loyal to Advantage at this point. Great price, great product, and it all come from a great company...." Read more

"Good value and keeps fleas away." Read more

"...If you have several cats or small dogs the price is prohibitive...." Read more

"...Great way to save money, same chemicals in the dog and cat for advantage. You just don’t want to over dose your cats. They are more sensitive...." Read more

24 customers mention24 positive0 negative

Customers are satisfied with the safety of the pet supplies. They mention that it is completely safe to use on cats, nursing kittens, and dogs. They also say that it doesn't cause any issues with their sensitive skin and doesn''t make them sick. Customers also mention that the doses are safe and reliable.

"...I bought this because it is recommended safe for rabbits by my vet, she gave me a dosing chart based on weight, it doesn't irritate their skin, and..." Read more

"This product has never caused an allergic reaction to my dog like cheaper products can do. Bio Spot is very harsh on delicate type dogs!..." Read more

"...The doses are safe and reliable. I think the worst symptom he gets is a little smelly breath, but that may even be something else...." Read more

"Very well flea medication. I use it for my dog. Never had any problems with side affects or reactions...." Read more

23 customers mention23 positive0 negative

Customers find the pet supplies easy to use. They say it works well, is simple, and does not need reapplying for many months.

"...Advantage 2 is easy to apply and comes in proportioned tubes...." Read more

"This is a great for controlling fleas! It really works and is relatively easy to apply. We have used it for quite awhile...." Read more

"...I find it works great right away and really doesn't need reapplying for many months after (despite what they tell you)...." Read more

"This is so easy to use. Does a great job of keeping fleas away. Just make sure you get it on every month and fleas won't come back." Read more

19 customers mention19 positive0 negative

Customers say the pet supplies are versatile. They say it's good for dogs, cats, and other pets. They also mention that it does a great job on their pets without any noticeable side effects.

"...Happy pets in the house now. Happy me as well!" Read more

"...No bad reactions from my pets and no fleas...." Read more

"...that the chemical in advantage, NOT advantix, is compatible for dogs and cats...." Read more

"This seems to work well, my dog has no problems with it and there are no flea or tick issues." Read more

18 customers mention7 positive11 negative

Customers are mixed about the scratch resistance of the pet supplies. Some mention that it works within a week to stop scratching and biting, while others say that it doesn't work and their dogs continue to scratch and itch.

"...That was a week ago and there is still scratching... Im not sure if it is because of where it is stored or D&M just received a bad batch, but the..." Read more

"...It has an ingredient that stops itching and eliminates rashes in about 3 days...." Read more

"...So far it seems to do the job. Some scratching. But I have not seen any fleas or ticks after many careful checks...." Read more

"...None of the cats stopped licking and chewing for even a day. I will have to capstar them to get them relief...." Read more

14 customers mention9 positive5 negative

Customers are mixed about the comfort of the pet supplies. Some mention that it doesn't irritate their skin, and it stops itching. They say it has an ingredient that stops itch and eliminates rashes in about 3 days. However, others say that when it's wearing off, they begin to get itchy and uncomfortable.

"...by my vet, she gave me a dosing chart based on weight, it doesn't irritate their skin, and the best part is they are flee free" Read more

"...I use it on all of them. It has an ingredient that stops itching and eliminates rashes in about 3 days...." Read more

"...the end of the month, when it's wearing off, they begin to get itchy and uncomfortable...." Read more

"...Within an hour, I notice a significant change in the comfort level of my outdoor dogs...." Read more

Works the 1st time! Even on ferrets
5 Stars
Works the 1st time! Even on ferrets
This is the ONLY brand I trust and will ever purchase. The formula is effective pretty quickly. My animals can't stand when I apply this to them but it is the only brand that I have found to ever kill and get rid of fleas completely, I've tried so many too! I use this on my ferrets too, but super carefully! I drip the formula into a glass vile and use a mL syringe. I've adopted many ferrets infested with fleas and this is the only formula that has ever successfully killed the fleas. It doesn't burn them, but they must be separated until it's completely dry or else they may get it in there mouths from playing with each other. Overall great product and a must-have in my home!
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Reviewed in the United States on September 12, 2015
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5.0 out of 5 stars Works the 1st time! Even on ferrets
Reviewed in the United States on October 13, 2023
This is the ONLY brand I trust and will ever purchase. The formula is effective pretty quickly. My animals can't stand when I apply this to them but it is the only brand that I have found to ever kill and get rid of fleas completely, I've tried so many too! I use this on my ferrets too, but super carefully! I drip the formula into a glass vile and use a mL syringe. I've adopted many ferrets infested with fleas and this is the only formula that has ever successfully killed the fleas. It doesn't burn them, but they must be separated until it's completely dry or else they may get it in there mouths from playing with each other. Overall great product and a must-have in my home!
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