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Advantage II XL Dog Vet-Recommended Flea Treatment & Prevention | Dogs Over 55 lbs. | 4-Month Supply
Return this item for free
Free returns are available for the shipping address you chose. You can return the item for any reason in new and unused condition: no shipping charges
Learn more about free returns.- Go to your orders and start the return
- Select the return method
- Ship it!
Purchase options and add-ons
Brand | Advantage |
Item Form | Topical |
Scent | Unscented |
Age Range (Description) | 7 weeks and older |
Item Weight | 0.1 Pounds |
Active Ingredients | Imidacloprid, Pyriproxyfen |
Item Volume | 16 Milliliters |
Target Species | Dog |
Allergen Information | Allergen-Free |
Dog Breed Size | Large |
About this item
- Vet recommended flea treatment and prevention for dogs at weighing over 55 lbs., at least 7 weeks of age
- Kills adult fleas, flea larvae and flea eggs for total flea prevention and treatment
- Same-day effectiveness, kills fleas within 12 hours of application and keeps working for 30 days
- Easy-to-apply topical treatment, no prescription needed
- Fragrance-free formula, waterproof after 24 hours
Customer ratings by feature
Frequently bought together
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From the manufacturer
Dog lovers choose Advantage II Extra Large Dog
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Kills and ProtectsKills adult fleas, flea larvae and flea eggs to break the flea life cycle and prevents flea and lice infestations for 30 days. |
Same-Day EffectivenessStarts to kill fleas and lice on dogs within 12 hours of application and continues to prevent reinfestations. |
Vet-RecommendedA leading brand in dog flea treatment and prevention, recommended for dogs over 55 lbs. |
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About Advantage II
*24 hours after application |
Easy Application - Step 1Holding the tube upright and pointed away from you and your pet, remove the cap from the applicator tube. Turn the cap around, place it back on the tube and twist to break the seal. |
Easy Application - Step 2Be sure to use the entire tube of Advantage II when applying it to your dog. Part the hair on your dog’s back between the shoulder blades until the skin is visible. Squeeze the tube to expel the entire contents directly on the skin in 1-4 spots, depending on your dog’s weight.See the product label for specific application instructions by weight. |
Advantage II Extra Large Dog | Seresto Large Dog | K9 Advantix II Extra Large Dog | advantus | Advantage Treatment Shampoo | |
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Customer Reviews |
4.5 out of 5 stars
2,971
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4.5 out of 5 stars
99,461
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4.5 out of 5 stars
42,528
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4.2 out of 5 stars
12,142
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4.4 out of 5 stars
1,666
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Form | Topical Drops | Collar | Topical Drops | Flea Soft Chew | Tick and Flea Shampoo |
Treatment | Treatment + Prevention | Treatment + Prevention | Treatment + Prevention | Treatment | Treatment |
Application Frequency | Monthly | Every 8 Months | Monthly | Do Not Exceed One Soft Chew in a 24-hour Period | See Product Label |
Kills Fleas? | ✓ | ✓ | ✓ | ✓ | ✓ |
Kills Ticks? | ― | ✓ | ✓ | ― | ― |
Starts to Kill Fleas Within | 12 hours | 24 hours | 12 hours | 1 hour | On Contact |
Product details
- Is Discontinued By Manufacturer : No
- Product Dimensions : 6.5 x 1 x 4.25 inches; 1.6 ounces
- Manufacturer recommended age : 1 month and up
- Item model number : 81520305
- Department : Unisex-Adult
- Date First Available : July 15, 2004
- Manufacturer : Elanco US Inc
- ASIN : B004QBL9IQ
- Best Sellers Rank: #16,241 in Pet Supplies (See Top 100 in Pet Supplies)
- #71 in Dog Flea Drops
- Customer Reviews:
Looking for specific info?
Product Description
Product Description
Advantage II Extra Large Dog is the vet-recommended prevention and treatment of flea and lice infestations in dogs. Advantage II Extra Large Dog flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your dog or puppy. In fact, within 12 hours of application, Advantage II Extra Large Dog topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your dog to die.
This 30-day treatment effectively breaks the flea life cycle, controlling existing flea and lice infestations and preventing further infestations all month long. Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Extra Large Dog is important to protect your dog against fleas that may cause transmission of tapeworms in dogs, Flea Allergy Dermatitis and flea bite anemia.
That’s why Advantage II topical, spot-on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.
Advantage II Extra Large Dog flea and lice protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh over 55 lbs. to use Advantage II Extra Large Dog.
For the ultimate convenience in care, Advantage II Extra Large Dog is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Once Advantage II Extra Large Dog is applied, your dog is ready to get right back to exploring his favorite places – from the backyard to the dog park.
Advantage II Extra Large Dog is a trademark of Elanco or its affiliates.
Brand Story
By Advantage
Videos
Videos for this product
1:08
Click to play video
How to apply Advantage II for Dogs
Elanco US Inc
Important information
Ingredients
Imidacloprid…………….9.10% Pyriproxyfen……………0.46% Other Ingredients………90.44% Total…………………….100.00%
Directions
Application Instructions: 1. Use only on dogs. 2. Hold applicator tube in an upright position. Pull cap off tube. 3. Turn the cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. 4. Apply the entire contents of the tube evenly to three or four spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. 5. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. 6. Do not apply an excessive amount of solution at any one spot that could cause the solution to run off the side of the dog. 7. Do not get this product in your dog’s eyes or allow them to ingest.
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Price | $47.96$47.96 | $55.96$55.96 | $34.98$34.98 | -6% $53.98$53.98 List: $57.48 | $79.98$79.98 | -11% $50.98$50.98 List: $57.58 |
Delivery | — | — | — | — | — | — |
Customer Ratings | ||||||
Easy to use | 4.3 | 4.6 | 3.9 | 4.2 | 4.2 | 4.1 |
Value for money | 3.6 | 3.5 | 3.4 | 3.5 | 3.4 | 3.4 |
Scent | — | 3.4 | 3.6 | — | 3.7 | 3.6 |
Comfort | 3.4 | — | — | 3.5 | 3.6 | — |
Sold By | Better Price For You LLC | Pets Go Here - Pet Store | Amazon.com | Reviluxe | Amazon.com | Amazon.com |
target audience | Dog, Dog, Dog Flea And Tick, Dog Flea And Tick Topicals, PetSupplies | Adult | — | Dog | Dog | Dog |
age range | 7 weeks and older | Kitten | 8 weeks and older | 7 weeks and older | 7 weeks and older | 7 weeks and older |
scent | Unscented | Unscented | Unscented | Unscented | — | Unscented |
form | Topical | Drops | Topical | Topical | Topical | Topical |
volume | 16 milliliters | 2 fluid ounces | 1 milliliters | 16 milliliters | 1 quarts | 10 milliliters |
active ingredients | Imidacloprid, Pyriproxyfen | — | Spinetoram | Imidacloprid, Permethrin, Pyriproxyfen | Imidacloprid, Permethrin, Pyriproxyfen | Imidacloprid, Pyriproxyfen |
weight | 0.1 pounds | 0.05 pounds | 0.71 ounces | 0.13 pounds | 0.15 pounds | 0.04 pounds |
Customer reviews
Customer Reviews, including Product Star Ratings help customers to learn more about the product and decide whether it is the right product for them.
To calculate the overall star rating and percentage breakdown by star, we don’t use a simple average. Instead, our system considers things like how recent a review is and if the reviewer bought the item on Amazon. It also analyzed reviews to verify trustworthiness.
Learn more how customers reviews work on AmazonCustomers say
Customers like the quality, value, ability to fleas and safety of the pet supplies. For example, they mention that it works well, is cost effective and worth the money. They appreciate the ease of use and versatility.
AI-generated from the text of customer reviews
Customers like the quality of the pet supplies. They say it works well, has amazing results, and is potent. Some say it's the best on the market.
"My dog had fleas…now she doesn’t! Works great!" Read more
"...The chemical that is in this product started out working very well. Over the years it seems to be losing its effectiveness earlier each month...." Read more
"...regularly gets into water (pool, beach, sprinklers), the Advantage wears off much quicker, despite claiming to be waterproof...." Read more
"...I didn't care for the smell, but man it's potent. My dog did not habe a seizure..." Read more
Customers like the ability of the pet supplies to keep fleas away. They mention that it not only kills the flea, but it also kills their eggs. Some say that after 3 days, almost all the flees are gone. Customers also say that it is the best topical flea control and that they have never seen flea on any of their cats.
"...Other than that, Advantage II is, in my opinion, the best topical flea control." Read more
"...but it is the only brand that I have found to ever kill and get rid of fleas completely, I've tried so many too!..." Read more
"...This stuff works great at killing fleas and preventing re infestation. I definitely recommend this product!..." Read more
"...I'm combing morning, noon and night it seems, and nothing. No dead fleas, no dying fleas, no die off in the carpets, and that despite the use of..." Read more
Customers like the value of the pet supplies. They mention that it's much more cost effective than the small dog or chewable, and worth the money.
"...I am brand loyal to Advantage at this point. Great price, great product, and it all come from a great company...." Read more
"Good value and keeps fleas away." Read more
"...If you have several cats or small dogs the price is prohibitive...." Read more
"...Great way to save money, same chemicals in the dog and cat for advantage. You just don’t want to over dose your cats. They are more sensitive...." Read more
Customers are satisfied with the safety of the pet supplies. They mention that it is completely safe to use on cats, nursing kittens, and dogs. They also say that it doesn't cause any issues with their sensitive skin and doesn''t make them sick. Customers also mention that the doses are safe and reliable.
"...I bought this because it is recommended safe for rabbits by my vet, she gave me a dosing chart based on weight, it doesn't irritate their skin, and..." Read more
"This product has never caused an allergic reaction to my dog like cheaper products can do. Bio Spot is very harsh on delicate type dogs!..." Read more
"...The doses are safe and reliable. I think the worst symptom he gets is a little smelly breath, but that may even be something else...." Read more
"Very well flea medication. I use it for my dog. Never had any problems with side affects or reactions...." Read more
Customers find the pet supplies easy to use. They say it works well, is simple, and does not need reapplying for many months.
"...Advantage 2 is easy to apply and comes in proportioned tubes...." Read more
"This is a great for controlling fleas! It really works and is relatively easy to apply. We have used it for quite awhile...." Read more
"...I find it works great right away and really doesn't need reapplying for many months after (despite what they tell you)...." Read more
"This is so easy to use. Does a great job of keeping fleas away. Just make sure you get it on every month and fleas won't come back." Read more
Customers say the pet supplies are versatile. They say it's good for dogs, cats, and other pets. They also mention that it does a great job on their pets without any noticeable side effects.
"...Happy pets in the house now. Happy me as well!" Read more
"...No bad reactions from my pets and no fleas...." Read more
"...that the chemical in advantage, NOT advantix, is compatible for dogs and cats...." Read more
"This seems to work well, my dog has no problems with it and there are no flea or tick issues." Read more
Customers are mixed about the scratch resistance of the pet supplies. Some mention that it works within a week to stop scratching and biting, while others say that it doesn't work and their dogs continue to scratch and itch.
"...That was a week ago and there is still scratching... Im not sure if it is because of where it is stored or D&M just received a bad batch, but the..." Read more
"...It has an ingredient that stops itching and eliminates rashes in about 3 days...." Read more
"...So far it seems to do the job. Some scratching. But I have not seen any fleas or ticks after many careful checks...." Read more
"...None of the cats stopped licking and chewing for even a day. I will have to capstar them to get them relief...." Read more
Customers are mixed about the comfort of the pet supplies. Some mention that it doesn't irritate their skin, and it stops itching. They say it has an ingredient that stops itch and eliminates rashes in about 3 days. However, others say that when it's wearing off, they begin to get itchy and uncomfortable.
"...by my vet, she gave me a dosing chart based on weight, it doesn't irritate their skin, and the best part is they are flee free" Read more
"...I use it on all of them. It has an ingredient that stops itching and eliminates rashes in about 3 days...." Read more
"...the end of the month, when it's wearing off, they begin to get itchy and uncomfortable...." Read more
"...Within an hour, I notice a significant change in the comfort level of my outdoor dogs...." Read more
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Top reviews from the United States
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The Advantage makes a noticeable difference in my pets' comfort- towards the end of the month, when it's wearing off, they begin to get itchy and uncomfortable. Once I reapply, that stops within a day or two, and they're happy and flea-free again all month.
I have noticed that if our dog regularly gets into water (pool, beach, sprinklers), the Advantage wears off much quicker, despite claiming to be waterproof. That's understandable in a topical treatment, so we try to keep her out of water until the end of the application cycle, before a new treatment- then she gets to get wet to her heart's content!
If you need to bathe your dog to kill fleas before applying, be sure to wait a day or two after the bath to give your dog's natural skin oils a chance to bounce back- it helps to distribute the medication.
Be aware: this product is alcohol-based, and will evaporate quickly if left out in open air (we use a glass baby food jar to split the dosages in the syringe). It has also stripped the lacquer off the dining table when a few drops spilled while splitting doses, so try to avoid that too! Other than that, Advantage II is, in my opinion, the best topical flea control.
Reviewed in the United States on October 13, 2023
Despite what sounds like negative aspects, the product worked for years and is better than being flea infested!! I am sad that it's loosing effect, so I have switched to a different product with a different chemical. Perhaps alternating chemical treatments from year to year would stop the fleas from building a resistance to one product??
Take off your dog's collar to ensure it doesn't slide down onto where you will be putting the Advantage. Open a package of Advantage and pour it into the jar. Pull into the syringe the right amount for your dog's weight:
0.4ml = 0-10#
0.8ml = 11-20#
1.2ml = 21-30#
1.6ml = 31-40#
2.0ml = 41-50#
2.4ml = 51-60#
2.8ml = 61-70#
3.2ml = 71-80#
You will put part of the Advantage on the dog's neck, and part of it in a few places down his back. Use your fingers to part the dog's hair on the back of his neck. (See package instructions on where to place the treatment.) Slowly depress the plunger onto the skin, NOT on top of the hair. Otherwise, it will drip off of the hair. Do several more spots down the dog's spine.
Immediately give treats to keep them from shaking their heads around. I learned the hard way that, if your dog vigorously shakes, this product can take the paint off cabinets and the varnish off stainless steel!! I do the treatment outside and leave the dogs outside for an hour or so.
Buying the largest size of Advantage and dosing several dogs with it can save a lot of money in the long run. Let's say your dog weighs 32 lbs, and you purchase the "Large dog for pets 21-55 lbs" and put the entire tube on him. You will be giving him 2.5 ML when he really only needs 1.6 ML. In a home with several dogs, this can add up!
Of course, talk to your vet if you have questions. This is just how I do it at my house! I am not a vet. I plan to post a video showing how I use this method.
**I have relied heavily on reviews for years, since I do most of my shopping online. I've finally starting trying to return the favor by writing reviews of products I love. I hope my review was helpful to you!**